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Ethyl acetate extracted from the chinese medicinal plant Caesalpinia sappan L alleviates gustatory response in diabetes mellitus rats

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机构： [1]Department of Endocrinology, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, PR China. [2]Department of Cardiovascular Disease, The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, PR China. [3]International Medical Center, Shenzhen University General Hospital, Shenzhen, Guangdong, PR China.

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关键词： Ethyl acetate extracts of Caesalpinia sappan L diabetes mellitus gustatory response taste-regulatory peptides vallate papillae hypothalamus

摘要：

The critical role of ethyl acetate (EtOAc) extracts of Caesalpinia sappan L (C. sappan) in disease control has been studied, while its potential function in diabetes mellitus (DM)-induced gustatory response remains unclear. Here, we focused on the regulatory role of EtOAc extracts of C. sappan in taste-regulatory peptides in vallate papillae and the hypothalamus.DM rat models were established using high-glucose and high-fat feeding combined with intraperitoneal injection of streptozotocin followed by administration of high, medium, and low doses of EtOAc extracts of C. sappan. Then, fasting blood glucose, triglycerides, and total cholesterol of rats were measured, the morphology of tongue vallate papillae and apoptosis of taste cells were detected by hematoxylin-eosin and TUNEL staining, and the expression of taste-regulatory peptides (ghrelin, GLP-1, NUCB2, and DPP-IV) in tongue tissue and hypothalamus was detected using RT-qPCR, Western blot, and immunohistochemistry.A high dose of EtOAc extracts of C. sappan reduced blood glucose and lipids, improved the morphology of tongue vallate papillae and neurons in the hypothalamus, and suppressed apoptosis of taste cells. In addition, both in taste cells and the hypothalamus, a high dose of EtOAc extracts of C. sappan elevated the expression of ghrelin, GLP-1, and NUCB2 but reduced DPP-IV expression.The current study highlighted the alleviative role of EtOAc extracts of C. sappan in gustatory response in DM rats via the regulation of taste-regulatory peptides in taste cells and the hypothalamus.©The Author(s) 2023. Open Access. This article is licensed under a Creative Commons CC-BY International License.

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出版当年[2022]版：

大类 | 4 区生物学

小类 | 4 区细胞生物学 4 区病理学

最新[2025]版：

大类 | 4 区生物学

小类 | 4 区细胞生物学 4 区病理学

第一作者：

第一作者机构： [1]Department of Endocrinology, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, PR China. [*1]Department of Endocrinology, First Affiliated Hospital of Harbin Medical University, No. 24 Youzheng Street, Harbin, Heilongjiang 150001, P.R. China

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通讯机构： [1]Department of Endocrinology, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, PR China. [*1]Department of Endocrinology, First Affiliated Hospital of Harbin Medical University, No. 24 Youzheng Street, Harbin, Heilongjiang 150001, P.R. China

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