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Enhanced cartilage regeneration by icariin and mesenchymal stem cell-derived extracellular vesicles combined in alginate-hyaluronic acid hydrogel

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收录情况： ◇ SCIE

作者：
Li Shuyi[1] * ; Yuan Qian[1] * ; Yang Minghui[1] * ; Long Xinyi[1] ; Sun Jianwu[1] ; Yuan Xin[1] ; Liu Lang[1] ; Zhang Wanting[1] ; Li Quanjiang[1] ; Deng Zhujie[1] ; Tian Rui[1] ; Xu Renhao[2] ; Xie Lingna[1] ; Yuan Jingna[3] ; He Yue[3] ; Liu Yi[4] ; Liu Hongmei[2] ; Yuan Zhengqiang[1] ;
机构： [1]School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, PR China [2]Department of Ultrasound, Institute of Ultrasound in Musculoskeletal Sports Medicine, Guangdong Second Provincial General Hospital, 510317 Guangzhou, PR China [3]Jinhang Bio-science and Biotechnology Co. Ltd, Guangzhou 510663, PR China [4]Orthopedics Department, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, PR China
出处：
DOI： 10.1016/j.nano.2023.102723
ISSN：

关键词： MSC spheroid culture Extracellular vesicle Icariin Cartilage regeneration Knee osteoarthritis

摘要：
Osteoarthritis (OA) is characterized by progressive cartilage degeneration and absence of curative therapies. Therefore, more efficient therapies are compellingly needed. Both mesenchymal stem cells (MSCs)-derived extracellular vesicles (EVs) and Icariin (ICA) are promising for repair of cartilage defect. This study proposes that ICA may be combined to potentiate the cartilage repair capacity of MSC-EVs.MSC-EVs were isolated from sodium alginate (SA) and hyaluronic acid (HA) composite hydrogel (SA-HA) cell spheroid culture. EVs and ICA were combined in SA-HA hydrogel to test therapeutic efficacy on cartilage defect in vivo.EVs and ICA were synergistic for promoting both proliferation and migration of MSCs and inflammatory chondrocytes. The combination therapy led to strikingly enhanced repair on cartilage defect in rats, with mechanisms involved in the concomitant modulation of both cartilage degradation and synthesis makers.The MSC-EVs-ICA/SA-HA hydrogel potentially constitutes a novel therapy for cartilage defect in OA.Copyright © 2023. Published by Elsevier Inc.

基金：
This work has been supported by the National Natural Science Foundation of China (grant number 82173850), the Guangdong Provincial Talented Scholar Foundation (220418137) and University Innovative Team Support for Major Chronic Diseases and Drug Development (26330320901).
语种：
外文
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中科院(CAS)分区：
出版当年[2023]版：
大类 | 2 区 医学
小类 | 3 区 医学：研究与实验 3 区 纳米科技
最新[2025]版：
大类 | 3 区 医学
小类 | 3 区 医学：研究与实验 3 区 纳米科技
JCR分区：
出版当年[2022]版：
Q2 MEDICINE, RESEARCH & EXPERIMENTAL Q2 NANOSCIENCE & NANOTECHNOLOGY
最新[2023]版：
Q2 MEDICINE, RESEARCH & EXPERIMENTAL Q2 NANOSCIENCE & NANOTECHNOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, PR China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Li Shuyi,Yuan Qian,Yang Minghui,et al.Enhanced cartilage regeneration by icariin and mesenchymal stem cell-derived extracellular vesicles combined in alginate-hyaluronic acid hydrogel[J].NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE.2024,55:doi:10.1016/j.nano.2023.102723.
APA：
Li Shuyi,Yuan Qian,Yang Minghui,Long Xinyi,Sun Jianwu...&Yuan Zhengqiang.(2024).Enhanced cartilage regeneration by icariin and mesenchymal stem cell-derived extracellular vesicles combined in alginate-hyaluronic acid hydrogel.NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,55,
MLA：
Li Shuyi,et al."Enhanced cartilage regeneration by icariin and mesenchymal stem cell-derived extracellular vesicles combined in alginate-hyaluronic acid hydrogel".NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 55.(2024)

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