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Spatholobus suberectus inhibits lipogenesis and tumorigenesis in triple-negative breast cancer via activation of AMPK-ACC and K-Ras-ERK signaling pathway

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Zeng Xiaohui[1,2] * ; Gong Guowei[1] ; Ganesan Kumar[1] ; Wen Yi[1,3] ; Liu Qingqing[1,4] ; Zhuo Juncheng[2] ; Wu Jianming[5] ; Chen Jianping[1,4,*1] ;
机构： [1]School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Sassoon Road, Pokfulam, Hong Kong, China. [2]Guangdong Second Traditional Chinese Medicine Hospital, Guangdong Province Engineering Technology Research Institute of Traditional Chinese Medicine, Guangzhou, Guangdong, 510095, China. [3]Zhongshan People's Hospital, 106, Zhongshan 2nd Road, Guangdong Province, 510080, China. [4]Shenzhen Institute of Research and Innovation, The University of Hong Kong, Shenzhen, 518000, China. [5]School of Pharmacy, Southwest Medical University, Luzhou, 646000, China.
出处：
DOI： 10.1016/j.jtcme.2023.09.002
ISSN：

关键词： Spatholobi suberectus Lipogenesis TNBC Therapy Natural product Proteomic and metabolomic analysis

摘要：
Triple-negative breast cancer (TNBC) is a highly invasive type of breast cancer with a poor prognosis. Currently, there are no effective management strategies for TNBC. Earlier, our lab reported the percolation of Spatholobus suberectus for the treatment of breast cancer. Lipid metabolic reprogramming is a hallmark of cancer. However, the anti-TNBC efficiency of S. suberectus extract and its causal mechanism for preventing lipogenesis have not been fully recognized. Hence, the present study aimed to investigate the inhibitory role of S. suberectus extract on lipogenesis and tumorigenesis in TNBC in vitro and in vivo by activating AMPK-ACC and K-Ras-ERK signaling pathways using lipidomic and metabolomic techniques.Dried stems of S. suberectus extract inhibited lipogenesis and tumorigenesis and promoted fatty acid oxidation as demonstrated by the identification of the metabolites and fatty acid markers using proteomic and metabolomic analysis, qPCR, and Western blot.The results indicated that S. suberectus extract promotes fatty acid oxidation and suppresses lipogenic metabolites and biomarkers, thereby preventing tumorigenesis via the AMPK-ACC and K-Ras-ERK signaling pathways. On the basis of this preclinical evidence, we suggest that this study represents a milestone and complements Chinese medicine. Further studies remain underway in our laboratory to elucidate the active principles of S. suberectus extract. This study suggests that S. suberectus extract could be a promising therapy for TNBC.© 2023 Center for Food and Biomolecules, National Taiwan University. Production and hosting by Elsevier Taiwan LLC.

基金：
This research was funded by the National Natural Science Foundation of China, China (81573663) and Guangxi Science and Technology Key Research and Development Program, China (AB16450012).
语种：
外文
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PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 3 区 医学
小类 | 2 区 全科医学与补充医学
最新[2025]版：
大类 | 3 区 医学
小类 | 3 区 全科医学与补充医学
JCR分区：
出版当年[2021]版：
Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE
最新[2023]版：
Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Sassoon Road, Pokfulam, Hong Kong, China. [2]Guangdong Second Traditional Chinese Medicine Hospital, Guangdong Province Engineering Technology Research Institute of Traditional Chinese Medicine, Guangzhou, Guangdong, 510095, China.
通讯作者：
通讯机构： [1]School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Sassoon Road, Pokfulam, Hong Kong, China. [4]Shenzhen Institute of Research and Innovation, The University of Hong Kong, Shenzhen, 518000, China. [*1]School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Sassoon Road, Pokfulam, Hong Kong, China.
推荐引用方式(GB/T 7714)：
Zeng Xiaohui,Gong Guowei,Ganesan Kumar,et al.Spatholobus suberectus inhibits lipogenesis and tumorigenesis in triple-negative breast cancer via activation of AMPK-ACC and K-Ras-ERK signaling pathway[J].Journal of traditional and complementary medicine.2023,13(6):623-638.doi:10.1016/j.jtcme.2023.09.002.
APA：
Zeng Xiaohui,Gong Guowei,Ganesan Kumar,Wen Yi,Liu Qingqing...&Chen Jianping.(2023).Spatholobus suberectus inhibits lipogenesis and tumorigenesis in triple-negative breast cancer via activation of AMPK-ACC and K-Ras-ERK signaling pathway.Journal of traditional and complementary medicine,13,(6)
MLA：
Zeng Xiaohui,et al."Spatholobus suberectus inhibits lipogenesis and tumorigenesis in triple-negative breast cancer via activation of AMPK-ACC and K-Ras-ERK signaling pathway".Journal of traditional and complementary medicine 13..6(2023):623-638

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