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Ginsenoside (20S)-protopanaxatriol induces non-protective autophagy and apoptosis by inhibiting Akt/mTOR signaling pathway in triple-negative breast cancer cells.

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资源类型：
Pubmed体系：
作者：
Yan Li[a] * ; Panpan Wang[b,c] * ; Zhuoling Zou[a] ; Qi Pan[a] ; Xiaoyun Li[c,d] ; Zien Liang[a] ; Lingyu Li[c,e] ; Yingbing Lin[a] ; Xueyu Peng[a] ; Ronghua Zhang[c,d,*2] ; Huaqin Tian[f] ; Li Han[b,*1] ;
机构： [a]College of Traditional Chinese Medicine, Jinan University, Guangzhou, Guangdong, 510630, PR China [b]First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, 510630, PR China [c]Guangdong Provincial Key Laboratory of Traditional Chinese Medicine Informatization Jinan University, Guangzhou, Guangdong, 510630, PR China [d]College of Pharmacy, Jinan University, Guangzhou, Guangdong, 510630, PR China [e]Cancer Research Institute, Jinan University, Guangzhou, Guangdong, 510630, PR China [f]Foshan Hospital of Traditional Chinese Medicine, Foshan, Guangdong, 528000, PR China
出处：
DOI： 10.1016/j.bbrc.2021.10.067
ISSN：

关键词： Triple negative breast cancer (TNBC) (20S)-Protopanaxatriol Autophagy Apoptosis Akt/mTOR signaling pathway

摘要：
Triple-negative breast cancer (TNBC) lacks a recognized therapeutic molecular target and has an unfavorable prognosis. (20S)-Protopanaxatriol (g-PPT, PPT) is an active metabolite extracted from ginseng. Accumulating evidence suggests that it has good anti-cancer activity in vivo and in vitro. In this study, we aimed to elucidate the anti-tumor effects of PPT in TNBC cells and tumor-bearing mice, as well as the relevant molecular mechanisms of autophagy and apoptosis. In vitro, we have found that PPT is capable of inducing non-protective autophagy and apoptosis, thus exerting some anti-proliferative and anti-migration activity in TNBC cells. And in vivo, the therapeutic effects of PPT were evaluated by xenograft mouse models. The potential binding mode of PPT and Akt was predicted by molecular docking. Our findings indicated that PPT treatment induced non-protective autophagy in TNBC cells by inhibiting the Akt/mTOR signaling pathway. Therefore, PPT may be a potential treatment for TNBC in the future.Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

基金：
Our work was supported by Guangdong Provincial Key Laboratory of Traditional Chinese Medicine Informatization (2021B1212040007), the National Natural Science Foundation of China (81603342), National Key R&D Program of China 2018YFC2002500, Foshan "Summit Plan" of building high-level hospitals, and the Administration of Traditional Chinese Medicine of Guangdong Province (No. 20171074).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类 | 3 区 生物
小类 | 3 区 生物物理 4 区 生化与分子生物学
最新[2025]版：
大类 | 4 区 生物学
小类 | 4 区 生化与分子生物学 4 区 生物物理
第一作者：
第一作者机构： [a]College of Traditional Chinese Medicine, Jinan University, Guangzhou, Guangdong, 510630, PR China
共同第一作者：
通讯作者：
通讯机构： [b]First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, 510630, PR China [c]Guangdong Provincial Key Laboratory of Traditional Chinese Medicine Informatization Jinan University, Guangzhou, Guangdong, 510630, PR China [d]College of Pharmacy, Jinan University, Guangzhou, Guangdong, 510630, PR China [*1]First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, 510630, PR China. [*2]Guangdong Provincial Key Laboratory of Traditional Chinese Medicine Informatization, Jinan University, Guangzhou, Guangdong, 510630, PR China.
推荐引用方式(GB/T 7714)：
Yan Li,Panpan Wang,Zhuoling Zou,et al.Ginsenoside (20S)-protopanaxatriol induces non-protective autophagy and apoptosis by inhibiting Akt/mTOR signaling pathway in triple-negative breast cancer cells.[J].Biochemical and biophysical research communications.2021,583:184-191.doi:10.1016/j.bbrc.2021.10.067.
APA：
Yan Li,Panpan Wang,Zhuoling Zou,Qi Pan,Xiaoyun Li...&Li Han.(2021).Ginsenoside (20S)-protopanaxatriol induces non-protective autophagy and apoptosis by inhibiting Akt/mTOR signaling pathway in triple-negative breast cancer cells..Biochemical and biophysical research communications,583,
MLA：
Yan Li,et al."Ginsenoside (20S)-protopanaxatriol induces non-protective autophagy and apoptosis by inhibiting Akt/mTOR signaling pathway in triple-negative breast cancer cells.".Biochemical and biophysical research communications 583.(2021):184-191

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