详情页 - 广东省中医院知识库

当前位置：首页 > 详情页

Significance of circulating tumor cells detection in tumor diagnosis and monitoring

文献详情

资源类型：

Pubmed体系：

作者：

机构： [1]Department of Laboratory Medicine, Nanfang Hospital, SouthernMedical University, Guangzhou, Guangdong 510515, China [2]Clinical Laboratory, Guangzhou 8th People’s Hospital, GuangzhouMedical University, Guangzhou, Guangdong 510060, China [3]Clinical Laboratory, The First Affiliated Hospital of Guangzhou Universityof Chinese Medicine, Guangzhou, Guangdong 510405, P.R. China

出处：

DOI：

关键词： Circulating Tumor cells Tumor diagnosis CTCs Tumor early detection

摘要：

To detect circulating tumor cells (CTCs) in the peripheral blood of patients with tumor, and to analyze the significance of CTC detection in tumor diagnosis and monitoring. In the present study, peripheral blood was collected from 125 patients with tumor, and CTCs were isolated and identified. Differences in CTC number and subtype detection were analyzed for different tumor diseases and stages. CTCs were detected in 122 of the 125 patients with tumor, with a positive rate of 97.6%. The number of CTCs increases in patients with vascular metastasis. The number of mesenchymal CTCs increases in patients with lymph node or vascular metastasis. The average ratio of epithelial CTCs in each positive sample decreases in the later stages of cancer compared with the earlier stages, while the average ratio of mesenchymal CTCs increases in the later stages of cancer compared with the earlier stages. The results showed that CTCs with mesenchymal phenotypes are closely related to lymph node or vascular metastasis. CTC detection can help with early diagnosis of tumor diseases. Continuous monitoring of changes in CTCs number and subtypes can assist clinical judgment of tumor disease development status and prognosis.© 2023. The Author(s).

基金：

语种：

PubmedID：

中科院(CAS)分区：

出版当年[2022]版：

大类 | 2 区

医学

小类 | 3 区肿瘤学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区肿瘤学

第一作者：

第一作者机构： [1]Department of Laboratory Medicine, Nanfang Hospital, SouthernMedical University, Guangzhou, Guangdong 510515, China

共同第一作者：

通讯作者：

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]Metabolic reprogramming-based characterization of circulating tumor cells in prostate cancer. [2]Covalent chemistry on nanostructured substrates enables noninvasive quantification of gene rearrangements in circulating tumor cells [3]Detection of HER2-positive Circulating Tumor Cells Using the LiquidBiopsy System in Breast Cancer. [4]Cascaded filter deterministic lateral displacement microchips for isolation and molecular analysis of circulating tumor cells and fusion cells [5]Metabolic classification of circulating tumor cells as a biomarker for metastasis and prognosis in breast cancer [6]Clinical Applications of NanoVelcro Rare-Cell Assays for Detection and Characterization of Circulating Tumor Cells [7]In Vivo Enrichment and Elimination of Circulating Tumor Cells by Using a Black Phosphorus and Antibody Functionalized Intravenous Catheter [8]Clinical significance of circulating tumor cells in predicting disease progression and chemotherapy resistance in patients with gestational choriocarcinoma [9]Ultrasound elastography as an imaging biomarker for detection of early tumor response to chemotherapy in a murine breast cancer model: a feasibility study [10]Prognostic significance of programmed cell death-ligand 1 expression on circulating tumor cells in various cancers: A systematic review and meta-analysis