机构：[1]Department of Hepatobiliary and Pancreatic Surgery The 2nd Clinical medical College (Shenzhen People’s Hospital) of Jinan University Shenzhen 518020, China深圳市康宁医院深圳市人民医院深圳医学信息中心[2]Department of Biomedical Engineering Southern University of Science and Technology Shenzhen 518055, China深圳市康宁医院深圳医学信息中心[3]Integrated Chinese and Western Medicine Postdoctoral research station Jinan University Guangzhou 510632, China[4]Shenzhen Second People’s Hospital The First Affiliated Hospital of Shenzhen University and Key Laboratoryof Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province Shenzhen University Shenzhen 518060, China深圳市第二人民医院深圳医学信息中心[5]School of Traditional Chinese Medicine Jinan University Guangzhou 510632, China[6]School of Biomedical and Pharmaceutical Sciences Guangdong University of Technology Guangzhou 510006, China
The circulating tumor cell (CTC) count is closely related to cancer recurrence and metastasis. The technology that can in vivo destroy CTCs may bring great benefits to patients, which is an urgent clinical demand. Here, a minimally invasive therapeutic intravenous catheter for in vivo enriching and photothermal killing of CTCs is developed. The surface of catheter is modified with anti-EpCAM antibody and the interior is filled with black phosphorus nanosheets (BPNSs). CTCs in the peripheral blood are captured by the catheter continually with the aid of circulation. The captured CTCs are used for downstream analyses or in vivo eliminated by the near-infrared (NIR) photothermal effect of BPNSs. A capture efficiency of 2.1% is obtained during the 5 min of treatment, and 100% of the captured CTCs are killed by following NIR light irradiation in both an in vitro closed-loop circulation system and an in vivo rabbit model. This cost-effective modality for lowering the CTCs burden can be a good supplement to traditional therapies, which holds great promise as an effective clinical intervention for cancer patients.
基金：
State Key Development Program for Basic Research of China [2019YFB2203503]; National Natural Science Foundation of China [81903131, 61875138, 81602608, U1801254]; China Postdoctoral Science Foundation [2018M643367]; Science and Technology Innovation Commission of Shenzhen [KQJSCX20180321164801762, JCYJ20180507181817604]; Guangdong Basic and Applied Basic Research Foundation [2019A1515110292]; Instrumental Analysis Center of Shenzhen University (Xili Campus)
第一作者机构：[1]Department of Hepatobiliary and Pancreatic Surgery The 2nd Clinical medical College (Shenzhen People’s Hospital) of Jinan University Shenzhen 518020, China[2]Department of Biomedical Engineering Southern University of Science and Technology Shenzhen 518055, China
通讯作者：
推荐引用方式(GB/T 7714)：
Dou Wang,Chenchen Ge,Weiyuan Liang,et al.In Vivo Enrichment and Elimination of Circulating Tumor Cells by Using a Black Phosphorus and Antibody Functionalized Intravenous Catheter[J].ADVANCED SCIENCE.2020,7(17):doi:10.1002/advs.202000940.
APA：
Dou Wang,Chenchen Ge,Weiyuan Liang,Qinhe Yang,Quan Liu...&Han Zhang.(2020).In Vivo Enrichment and Elimination of Circulating Tumor Cells by Using a Black Phosphorus and Antibody Functionalized Intravenous Catheter.ADVANCED SCIENCE,7,(17)
MLA：
Dou Wang,et al."In Vivo Enrichment and Elimination of Circulating Tumor Cells by Using a Black Phosphorus and Antibody Functionalized Intravenous Catheter".ADVANCED SCIENCE 7..17(2020)
工程技术