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Association between pre-ICU statin use and ARDS mortality in the MIMIC-IV database: a cohort study

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机构: [1]Hangzhou Med Coll, Zhejiang Prov Peoples Hosp, Affiliated Peoples Hosp, Ctr Rehabil Med,Dept Anesthesiol, Hangzhou, Zhejiang, Peoples R China [2]Guangzhou Univ Chinese Med, Affiliated Hosp 2, Dept Crit Care Med, Guangzhou, Guangdong, Peoples R China [3]Sun Yat Sen Univ, Affiliated Hosp 1, Dept Pulm & Crit Care Med, Guangzhou, Guangdong, Peoples R China [4]Sun Yat Sen Univ, Guangxi Hosp Div, Dept Pulm & Crit Care Med, Hosp 1, Nanning, Peoples R China [5]Hangzhou Med Coll, Emergency & Crit Care Ctr, Dept Emergency Med, Zhejiang Prov Peoples Hosp,Affiliated Peoples Hosp, Hangzhou, Zhejiang, Peoples R China
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关键词: ICU Medical Information Mart for Intensive Care-IV statins cohort study mortality

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BackgroundAcute respiratory distress syndrome (ARDS) is a severe condition associated with high morbidity, mortality, and healthcare costs. Despite extensive research, treatment options for ARDS are suboptimal.MethodsThis study encompassed patients diagnosed with ARDS from the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database. Pre-intensive care unit (ICU) statin use was assessed as the exposure variable. Kaplan-Meier survival analysis was conducted to evaluate mortality at 30 and 90 days. Adjusted multivariable Cox models were utilized to estimate hazard ratios. Subgroup analyses and propensity score-matching (PSM) were undertaken for further validation.ResultsOur study comprised 10,042 participants diagnosed with ARDS, with an average age of 61.8 +/- 15.3 years. Kaplan-Meier survival analysis demonstrated a significantly lower prevalence of mortality at 30 and 90 days in individuals who used statins before ICU admission. Adjusted multivariable Cox models consistently showed a significant decrease in mortality prevalence associated with pre-ICU statin use. After accounting for confounding factors, patients who used statins before ICU admission experienced a 39% reduction in 30-day mortality and 38% reduction in 90-day mortality. We found a significant decrease in ICU stay (0.84 days) for those who used statins before ICU admission. These results were supported by subgroup analyses and PSM.ConclusionThis large cohort study provides evidence supporting the association between pre-ICU statin use, reduced risk of death, and shorter ICU stay in patients with ARDS, thereby suggesting the potential benefits of statin use in critically ill patients.

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出版当年[2022]版:
大类 | 3 区 医学
小类 | 3 区 医学:内科
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大类 | 3 区 医学
小类 | 3 区 医学:内科
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Q2 MEDICINE, GENERAL & INTERNAL
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Q1 MEDICINE, GENERAL & INTERNAL

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第一作者机构: [1]Hangzhou Med Coll, Zhejiang Prov Peoples Hosp, Affiliated Peoples Hosp, Ctr Rehabil Med,Dept Anesthesiol, Hangzhou, Zhejiang, Peoples R China
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