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Associations of MMP9 polymorphism with the risk of severe pneumonia in a Southern Chinese children population

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收录情况： ◇ SCIE

作者：
Cai Li[1] * ; Zuo Xiaoyu[2] * ; Ma Liuheyi[2] ; Zhang Yuxia[2] ; Xu Falin[3] ; Lu Bingtai[2,4] ;
机构： [1]Department of Hospital Infection Control, The Second Afliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510120, China [2]Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, China [3]Department of Pediatrics, The Third Afliated Hospital of Zhengzhou University, Zhengzhou, Henan Province 450052, China [4]Medical Research Institute, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University Guangzhou, Guangzhou, Guangdong 510080, China
出处：
DOI： 10.1186/s12879-023-08931-4
ISSN：

关键词： Pneumonia MMP9 Single nucleotide polymorphism

摘要：
Severe pneumonia frequently causes irreversible sequelae and represents a major health burden for children under the age of 5. Matrix Metallopeptidase 9 (MMP9) is a zinc-dependent endopeptidase that is involved in various cellular processes. The correlation between MMP9 and the risk of severe childhood pneumonia remains unclear.Here we assemble a case-control cohort to study the association of genetic variants in MMP9 gene with severe childhood pneumonia susceptibility in a Southern Chinese population (1034 cases and 8426 controls).Our results indicate that the allele G in rs3918262 SNP was significantly associated with an increased risk of severe pneumonia. Bioinformatic analyses by expression quantitative trait loci (eQTL), RegulomeDB and FORGEdb database analysis showed that rs3918262 SNP has potential regulatory effect on translational efficiency and protein level of MMP9 gene. Furthermore, MMP9 concentrations were significantly up-regulated in the bronchoalveolar lavages (BALs) of children with severe pneumonia.In summary, our findings suggest that MMP9 is a novel predisposing gene for childhood pneumonia.© 2023. The Author(s).

基金：
National Natural Science Foundation of China (82001676 to B.L.)
语种：
外文
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PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 3 区 医学
小类 | 3 区 传染病学
最新[2025]版：
大类 | 3 区 医学
小类 | 3 区 传染病学
JCR分区：
出版当年[2022]版：
Q3 INFECTIOUS DISEASES
最新[2023]版：
Q2 INFECTIOUS DISEASES

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]Department of Hospital Infection Control, The Second Afliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510120, China
共同第一作者：
通讯作者：
通讯机构： [2]Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, China [4]Medical Research Institute, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University Guangzhou, Guangzhou, Guangdong 510080, China
推荐引用方式(GB/T 7714)：
Cai Li,Zuo Xiaoyu,Ma Liuheyi,et al.Associations of MMP9 polymorphism with the risk of severe pneumonia in a Southern Chinese children population[J].BMC INFECTIOUS DISEASES.2024,24(1):19.doi:10.1186/s12879-023-08931-4.
APA：
Cai Li,Zuo Xiaoyu,Ma Liuheyi,Zhang Yuxia,Xu Falin&Lu Bingtai.(2024).Associations of MMP9 polymorphism with the risk of severe pneumonia in a Southern Chinese children population.BMC INFECTIOUS DISEASES,24,(1)
MLA：
Cai Li,et al."Associations of MMP9 polymorphism with the risk of severe pneumonia in a Southern Chinese children population".BMC INFECTIOUS DISEASES 24..1(2024):19

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