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Exploring a novel therapeutic strategy: the interplay between gut microbiota and high-fat diet in the pathogenesis of metabolic disorders

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机构： [1]School of Traditional Chinese Medicine, Hainan Medical University, Haikou, Hainan, China. [2]School of Basic Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China. [3]The Affiliated TCM Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.

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关键词： gut microbiota high-fat diet metabolic disorders pathogenesis therapeutic strategies

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In the past two decades, the rapid increase in the incidence of metabolic diseases, including obesity, diabetes, dyslipidemia, non-alcoholic fatty liver disease, hypertension, and hyperuricemia, has been attributed to high-fat diets (HFD) and decreased physical activity levels. Although the phenotypes and pathologies of these metabolic diseases vary, patients with these diseases exhibit disease-specific alterations in the composition and function of their gut microbiota. Studies in germ-free mice have shown that both HFD and gut microbiota can promote the development of metabolic diseases, and HFD can disrupt the balance of gut microbiota. Therefore, investigating the interaction between gut microbiota and HFD in the pathogenesis of metabolic diseases is crucial for identifying novel therapeutic strategies for these diseases. This review takes HFD as the starting point, providing a detailed analysis of the pivotal role of HFD in the development of metabolic disorders. It comprehensively elucidates the impact of HFD on the balance of intestinal microbiota, analyzes the mechanisms underlying gut microbiota dysbiosis leading to metabolic disruptions, and explores the associated genetic factors. Finally, the potential of targeting the gut microbiota as a means to address metabolic disturbances induced by HFD is discussed. In summary, this review offers theoretical support and proposes new research avenues for investigating the role of nutrition-related factors in the pathogenesis of metabolic disorders in the organism.Copyright © 2023 Jia, Chen, Wu, Liu, Jing, Gong and Zhang.

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出版当年[2022]版：

大类 | 2 区农林科学

小类 | 2 区营养学

最新[2025]版：

大类 | 2 区农林科学

小类 | 3 区营养学

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第一作者机构： [1]School of Traditional Chinese Medicine, Hainan Medical University, Haikou, Hainan, China.

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