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Using intravoxel incoherent motion imaging to evaluate uric acid-induced renal injury and efficacy after treatment

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机构： [1]Medical Imaging Department, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, China. [2]Nephrology Department, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, China. [3]New Medicine Department, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, China. [4]Traditional Chinese Medicine Department, Lecong Hospital of Shunde, Foshan 528315, China. [5]Department of Radiology, The Affiliated Shunde Hospital of Jinan University, Foshan, Guangdong Province 528306, China. [6]Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100091, China.

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关键词： intravoxel incoherent motion hyperuricaemia kidney injury uric acid lowering therapy

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To validate the feasibility of intravoxel incoherent motion imaging (IVIM) for monitoring renal injury and uric acid-lowering efficacy in a rat model of hyperuricaemia.A total of 92 rats were analysed and categorized into 4 groups: control (CON), hyperuricaemia (HUA), allopurinol intervention (ALL), and combined intervention (COM). Eight rats were randomly selected from each group and underwent IVIM scanning on days 0, 1, 3, 5, 7, and 9. Quantitative magnetic resonance values (D, D*, and f values) measured from the different renal anatomical regions. Quantitative histopathological analysis was performed to assess renal tubular injury using neutrophil gelatinase-associated lipocalin (NGAL), and renal fibrosis using alpha-smooth-muscle-actin (α-SMA). Pearson's correlation analysis was used to determine the correlation between IVIM-derived parameters and the expression of NGAL and α-SMA.The D values of the HUA, ALL, and COM groups generally showed a downward trend over time, and this fluctuation was most significant in the HUA group. The D values showed significant intergroup differences at each point, whereas only a few discrepancies were found in the D* and f values. In addition, the renal D value was negatively correlated with the positive staining rates for NGAL and α-SMA (P < .05), except for the lack of correlation between Dos and α-SMA (P > .05).IVIM could be a noninvasive and potential assessment modality for the evaluation of renal injury induced by hyperuricaemia and its prognostic efficacy.IVIM could be a surrogate manner in monitoring renal damage induced by hyperuricaemia and its treatment evaluation.© The Author(s) 2023. Published by Oxford University Press on behalf of the British Institute of Radiology. All rights reserved. For permissions, please email: journals.permissions@oup.com.

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出版当年[2023]版：

大类 | 4 区医学

小类 | 4 区核医学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区核医学

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第一作者机构： [1]Medical Imaging Department, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, China.

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Using intravoxel incoherent motion imaging to evaluate uric acid-induced renal injury and efficacy after treatment

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