详情页 - 广东省中医院知识库

当前位置：首页 > 详情页

The role of ABCC10/MRP7 in anti-cancer drug resistance and beyond

文献详情

资源类型：

Pubmed体系：

作者：

机构： [1]Department of Medical Oncology, Shenzhen Longhua District Central Hospital, Shenzhen, Guangdong 518100, China [2]Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John’s University, Queens, NY 11439, USA [3]Institute for Biotechnology, St. John’s University, Queens, NY 11439, USA [4]CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China [5]Department of Pharmacy, Shenzhen Longhua District Central Hospital, Shenzhen, Guangdong 518100, China [6]New York College of Traditional Chinese Medicine, Mineola, NY 11501, USA

出处：

DOI：

ISSN：

关键词： ABCC10/MRP7 Multidrug Resistance (MDR) Cancer Taxanes Vinca Alkaloids

摘要：

Multidrug resistance protein 7 (MRP7), also known as ATP-binding cassette (ABC) transporter subfamily C10 (ABCC10), is an ABC transporter that was first identified in 2001. ABCC10/MRP7 is a 171 kDa protein located on the basolateral membrane of cells. ABCC10/MRP7 consists of three transmembrane domains and two nucleotide binding domains. It mediates multidrug resistance of tumor cells to a variety of anticancer drugs by increasing drug efflux and results in reducing intracellular drug accumulation. The transport substrates of ABCC10/MRP7 include antineoplastic drugs such as taxanes, vinca alkaloids, and epothilone B, as well as endobiotics such as leukotriene C4 (LTC4) and estradiol 17 β-D-glucuronide. A variety of ABCC10/MRP7 inhibitors, including cepharanthine, imatinib, erlotinib, tariquidar, and sildenafil, can reverse ABCC10/MRP7-mediated MDR. Additionally, the presence or absence of ABCC10/MRP7 is also closely related to renal tubular dysfunction, obesity, and other diseases. In this review, we discuss: 1) Structure and functions of ABCC10/MRP7; 2) Known substrates and inhibitors of ABCC10/MRP7 and their potential therapeutic applications in cancer; and 3) Role of ABCC10/MRP7 in non-cancerous diseases.Copyright © 2024 Elsevier Ltd. All rights reserved.

语种：

PubmedID：

中科院(CAS)分区：

出版当年[2023]版中科院分区表Review为是的期刊

：

大类 | 1 区医学

小类 | 1 区药学

最新[2025]版

：

大类 | 1 区

医学

小类 | 1 区药学

第一作者：

第一作者机构： [1]Department of Medical Oncology, Shenzhen Longhua District Central Hospital, Shenzhen, Guangdong 518100, China

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]M3814, a DNA-PK Inhibitor, Modulates ABCG2-Mediated Multidrug Resistance in Lung Cancer Cells [2]Paris saponin VII reverses chemoresistance in breast MCF-7/ADR cells. [3]Desacetylvinblastine Monohydrazide Disrupts Tumor Vessels by Promoting VE-cadherin Internalization. [4]The effect and mechanism of YH0618 granule on chemotherapy- induced hair loss in patients with breast cancer: study protocol for a randomized, double-blind, multi-center clinical trial [5]宫颈癌患者放疗期间的中西医护理 [6]AMPK and Cancer. [7]结肠癌组织和癌旁组织miRNA表达谱研究 [8]Functionalization and cancer-targeting design of ruthenium complexes for precise cancer therapy [9]Familial association of lung cancer with liver cancer in first-degree relatives [10]Attitudes of breast cancer associated doctors toward procreation in young patients with early breast cancer