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Exosomal circ_0037104 derived from Hu-MSCs inhibits cholangiocarcinoma progression by sponging miR-620 and targeting AFAP1

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机构： [1]Department of Medical Laboratory Center, General Hospital of Central Theatre Command of People's Liberation Arm, Wuhan, Hubei, China. [2]Oncology Department, Maoming Hospital of Traditional Chinese Medicine, Maoming, Guangdong, China. [3]Applied Mathematics, School of Mathematics and Physics, Xi'an Jiaotong-Liverpool University, Suzhou, Jiangsu, China.

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关键词： apoptotic peptidase activating factor 1 cholangiocarcinoma circ_0037104 exosomes mesenchymal stem cells

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Exosomes are membrane-enclosed nanovesicles that shuttle active cargoes, such as circular RNAs (circRNAs) and microRNAs (miRNAs), between different cells. Human umbilical cord-derived mesenchymal stem cells (Hu-MSCs) can migrate to tumor sites and exert complex functions throughout tumor progression. In this study, we successfully isolated Hu-MSCs from human umbilical cords based on their surface marker expression. Hu-MSC-derived exosomes significantly reduced the invasion, migration, and proliferation of cholangiocarcinoma (CCA) cells. Furthermore, circ_0037104 was downregulated in CCA and inhibited the proliferation and metastasis of CCA cells. Then, we investigated the effect of Hu-MSC-derived exosomal circ_0037104 on CCA. Circ_0037104 mainly regulates miR-620 and enhances APAF1 expression, inhibiting CCA cell proliferation and metastasis. Overall, Hu-MSC exosomal circ_0037104 contributes to the progression and stemness of CCA cells via miR-620/APAF1. In conclusion, Hu-MSC-derived exosomal circ_0037104 sponges miR-620 directly and negatively targets APAF1 to suppress CCA.© 2024 The Authors. Journal of Biochemical and Molecular Toxicology published by Wiley Periodicals LLC.

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出版当年[2023]版：

大类 | 3 区医学

小类 | 3 区生化与分子生物学 3 区毒理学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区生化与分子生物学 3 区毒理学

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第一作者机构： [1]Department of Medical Laboratory Center, General Hospital of Central Theatre Command of People's Liberation Arm, Wuhan, Hubei, China.

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