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Polystyrene microplastics induce anxiety via HRAS derived PERK-NF-κB pathway

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资源类型：
Pubmed体系：
作者：
Li Guanjun[1] * ; Liu Xueyan[1] * ; Sun Xin[2] * ; Huang Ling[1] ; Kuang Wenhua[1] ; Ou Jinhuan[1] ; Zhang Junzhe[3] ; Zhang Ziyue[1] ; Li Huiying[4] ; Tang Huan[3] ; Feng Chenran[3] ; Gu Liwei[3] ; Yang Chuanbin[1] ; Peili Wang[6] ; Wang Jigang[1,3,4,5] ;
机构： [1]Department of Critical Medicine, Shenzhen Clinical Research Centre for Geriatrics, Shenzhen People’s Hospital, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen 518020, Guangdong, China [2]Department of Cardiology, Shenzhen Cardiovascular Minimally Invasive Medical Engineering Technology Research and Development Center, Shenzhen People’s Hospital, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen 518020, Guangdong, China [3]State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, and Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China [4]Dongguan Maternal and Child Health Care Hospital, Postdoctoral Innovation Practice Base of Southern Medical University, Dongguan 523125, Guangdong, China [5]State Key Laboratory of Antiviral Drugs, School of Pharmacy, Henan University, Kaifeng 475004, China [6]National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China
出处：
DOI： 10.1016/j.envint.2024.108543
ISSN：

关键词： Polystyrene microplastics Environmental toxicology Analytical chemistry

摘要：
Exposure to environmentally hazardous substances is recognized as a significant risk factor for neurological associated disorders. Among these substances, polystyrene microplastics (PS-MPs), widely utilized in various consumer products, have been reported to exhibit neurotoxicity. However, the potential association of PS-MPs with abnormal anxiety behaviors, along with the underlying molecular mechanisms and key proteins involved, remains insufficiently explored. Here, we delineated the potential mechanisms of PS-MPs-induced anxiety through proteomics and molecular investigations. We characterized the PS-MPs, observed their accumulation in the brain, leading to anxiety-like behavior in mice, which is correlated with microglia activation and pro-inflammatory response. Consistent with these findings, our studies on BV2 microglia cells showed that PS-MPs activated NF-κB-mediated inflammation resulting in the upregulation of pro-inflammatory cytokines such as TNFα and IL-1β. Of particular significance, HRAS was identified as a key factor in the PS-MPs induced pro-inflammatory response through whole proteomics analysis, and knockdown of H-ras effectively inhibited PS-MPs induced PERK-NF-κB activation and associated pro-inflammatory response in microglia cells. Collectively, our findings highlight that PS-MPs induce anxiety of mice via the activation of the HRAS-derived PERK-NF-κB pathway in microlglia. Our results contribute valuable insights into the molecular mechanisms of PS-MPs-induced anxiety, and may offer implications for addressing neurotoxicity and prevention the adverse effects of environmentally hazardous substances, including microplastics.Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.

基金：
Scientific and technological innovation project of China Academy of Chinese Medical Sciences (CI2023D003, CI2021B014); the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine (No: ZYYCXTD-C-202002); the CACMS Innovation Fund (CI2023E002, CI2021A05101 and CI2021A05104); the Science and Technology Foundation of Shenzhen (JCYJ20210324115800001); the Science and Technology Foundation of Shenzhen (Shenzhen Clinical Medical Research Center for Geriatric Diseases); the Shenzhen Medical Research Fund (B2302051); the Distinguished Expert Project of Sichuan Province Tianfu Scholar (CW202002); the study was supported by the Shenzhen Key Laboratory of Prevention and Treatment of Severe Infections (Grant No. ZDSYS20200811142804014); the Shenzhen Science and Technology Innovation Committee (SZSTI) (RCYX20221008092950121); the National Natural Science Foundation of China (82070517); the Major scientific research project of Shenzhen People’s Hospital (SYWGSJCYJ202202); the Natural Science Foundation of Shenzhen for basic research (JCYJ20230807111911024 and JCYJ20230807111959039), and China Postdoctoral Science Foundation (2023M741600).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 1 区 环境科学与生态学
小类 | 1 区 环境科学
最新[2025]版：
大类 | 1 区 环境科学与生态学
小类 | 1 区 环境科学
第一作者：
第一作者机构： [1]Department of Critical Medicine, Shenzhen Clinical Research Centre for Geriatrics, Shenzhen People’s Hospital, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen 518020, Guangdong, China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Critical Medicine, Shenzhen Clinical Research Centre for Geriatrics, Shenzhen People’s Hospital, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen 518020, Guangdong, China [3]State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, and Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China [4]Dongguan Maternal and Child Health Care Hospital, Postdoctoral Innovation Practice Base of Southern Medical University, Dongguan 523125, Guangdong, China [5]State Key Laboratory of Antiviral Drugs, School of Pharmacy, Henan University, Kaifeng 475004, China
推荐引用方式(GB/T 7714)：
Li Guanjun,Liu Xueyan,Sun Xin,et al.Polystyrene microplastics induce anxiety via HRAS derived PERK-NF-κB pathway[J].Environment International.2024,185:108543.doi:10.1016/j.envint.2024.108543.
APA：
Li Guanjun,Liu Xueyan,Sun Xin,Huang Ling,Kuang Wenhua...&Wang Jigang.(2024).Polystyrene microplastics induce anxiety via HRAS derived PERK-NF-κB pathway.Environment International,185,
MLA：
Li Guanjun,et al."Polystyrene microplastics induce anxiety via HRAS derived PERK-NF-κB pathway".Environment International 185.(2024):108543

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