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An anti-infection and biodegradable TFRD-loaded porous scaffold promotes bone regeneration in segmental bone defects -experimental studies

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资源类型：
Pubmed体系：
作者：
Lin Haixiong[1,2,3] * ; Li Zige[4] ; Xie Zhenze[5] ; Tang Shengyao[6] ; Huang Minling[7] ; Feng Junjie[8] ; Wei Yuhan[9] ; Shen Zhen[10] ; Zhou Ruoyu[11] ; Feng Yuanlan[12] ; Chen Huamei[13] ; Ren Yueyi[3] ; Huang Feng[14] ; Wang Xiaotong[9,*2] ; Jiang Ziwei[14,*1] ;
机构： [1]Center for Neuromusculoskeletal Restorative Medicine & Institute for TissueEngineering and Regenerative Medicine, The Chinese University of Hong Kong,Hong Kong SAR 999077, China [2]Department of Orthopaedics, Ningxia Hui Autonomous Region Hospital andResearch Institute of Traditional Chinese Medicine, Yinchuan 750021, China [3]The First School of Clinical Medicine, Guangzhou University of Chinese Medicine,Guangzhou 510405, China [4]The 2nd Department of Arthrosis, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing 100000, China [5]Department of Biomedical Engineering, School of Materials Science andEngineering, South China University of Technology, Guangzhou 510641, China [6]Department of Orthopaedics, Guangdong Second Hospital of Traditional ChineseMedicine & Guangdong Province Engineering Technology Research Institute ofTraditional Chinese Medicine, Guangzhou 510095, China [7]Department of Diabetes, Central Clinical School, Monash University, Melbourne3004,Victoria, Australia [8]Emergency Department, Dongguan People's Hospital, Dongguan 523000, China [9]School of Acupuncture-Moxibustion and Tuina, Beijing University of ChineseMedicine, Beijing 102488, China [10]Department of Rehabilitation, Kunming Municipal Hospital of Traditional ChineseMedicine, The Third Affiliated Hospital of Yunnan University of Chinese Medicine,Kunming 650011, China [11]Department of Orthopaedics, Nanchang Hongdu Hospital of Traditional ChineseMedicine, Nanchang 330000, China [12]Fifth Department of Orthopedics (Foot and Ankle Surgery), Shunde Hospital ofGuangzhou University of Chinese Medicine, Foshan 528300, China [13]Department of Orthopedic Surgery, Orthopedic Hospital of Guangzhou,Guangzhou 510045, China [14]Department of Orthopaedics & Traumatology, The First Affiliated Hospital ofGuangzhou University of Chinese Medicine, Guangzhou 510405, People's Republicof China
出处：
DOI： 10.1097/JS9.0000000000001291
ISSN：

关键词： Drug delivery scaffold Bone microenvironment Bone defect Angiogenesis

摘要：
Addressing segmental bone defects remains a complex task in orthopedics, and recent advancements have led to the development of novel drugs to enhance the bone regeneration. However, long-term oral administration can lead to malnutrition and poor patient compliance. Scaffolds loaded with medication are extensively employed to facilitate the restoration of bone defects.Inspired by the local use of total flavonoids of Rhizoma Drynariae (TFRD) in the treatment of fracture, a novel 3D-printed HA/CMCS/PDA/TFRD scaffold with anti-infection, biodegradable and induced angiogenesis was designed, and to explore its preclinical value in segmental bone defect of tibia.The scaffold exhibited good degradation and drug release performance. In vitro, the scaffold extract promoted osteogenesis by enhancing bone-related gene/protein expression and mineral deposition in BMSCs. It also stimulated endothelial cell migration and promoted angiogenesis through the upregulation of specific genes and proteins associated with cell migration and tube formation. This may be attributed to the activation of the PI3k/AKT/HIF-1α pathway, facilitating the processes of osteogenesis and angiogenesis. Furthermore, the HA/CMCS/PDA/TFRD scaffold was demonstrated to alleviate infection, enhance angiogenesis, promote bone regeneration, and increase the maximum failure force of new formed bone in a rat model of segmental bone defects.Porous scaffolds loaded with TFRD can reduce infection, be biodegradable, and induce angiogenesis, presenting a novel approach for addressing tibial segmental bone defects.Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.

基金：
This work was supported, in part, by National Natural Science Foundation of China (No. 81974575), Special Funds for the Discipline Reserve Talent Cultivation Project of Guangzhou University of Chinese Medicine “Double First-Class” and High-level University Construction, and Cultivation of Young and Middle-aged Talents in the First Affiliated Hospital of Guangzhou University of Chinese medicine (2023).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 2 区 医学
小类 | 2 区 外科
最新[2025]版：
大类 | 2 区 医学
小类 | 2 区 外科
第一作者：
第一作者机构： [1]Center for Neuromusculoskeletal Restorative Medicine & Institute for TissueEngineering and Regenerative Medicine, The Chinese University of Hong Kong,Hong Kong SAR 999077, China [2]Department of Orthopaedics, Ningxia Hui Autonomous Region Hospital andResearch Institute of Traditional Chinese Medicine, Yinchuan 750021, China [3]The First School of Clinical Medicine, Guangzhou University of Chinese Medicine,Guangzhou 510405, China
通讯作者：
通讯机构： [9]School of Acupuncture-Moxibustion and Tuina, Beijing University of ChineseMedicine, Beijing 102488, China [14]Department of Orthopaedics & Traumatology, The First Affiliated Hospital ofGuangzhou University of Chinese Medicine, Guangzhou 510405, People's Republicof China [*1]The First Affiliated Hospital of Guangzhou University of Chinese Medicine, NO.16 Jichang Road, Baiyun District, Guangzhou 510405, People's Republic of China. [*2]School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Liangxiang Campus of Beijing University of Chinese Medicine, Liangxiang Higher Education Park, Fangshan District, Beijing 102488, China.
推荐引用方式(GB/T 7714)：
Lin Haixiong,Li Zige,Xie Zhenze,et al.An anti-infection and biodegradable TFRD-loaded porous scaffold promotes bone regeneration in segmental bone defects -experimental studies[J].International Journal Of Surgery (London, England).2024,doi:10.1097/JS9.0000000000001291.
APA：
Lin Haixiong,Li Zige,Xie Zhenze,Tang Shengyao,Huang Minling...&Jiang Ziwei.(2024).An anti-infection and biodegradable TFRD-loaded porous scaffold promotes bone regeneration in segmental bone defects -experimental studies.International Journal Of Surgery (London, England),,
MLA：
Lin Haixiong,et al."An anti-infection and biodegradable TFRD-loaded porous scaffold promotes bone regeneration in segmental bone defects -experimental studies".International Journal Of Surgery (London, England) .(2024)

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