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Role of TGF‑β1 expressed in bone marrow‑derived mesenchymal stem cells in promoting bone formation in a rabbit femoral defect model(Open Access)

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收录情况： ◇ SCIE

作者：
Bing‑Yin Sun[1] * ; Bao‑Xiang Zhao[2] * ; Jie‑Ying Zhu[3] ; Zheng‑Ping Sun[4] ; Yong‑An Shi[5] ; Feng Huang[6,*1] ;
机构： [1]Department of Orthopedics, Shunde Hospital of Guangzhou University of Chinese Medicine, Foshan, Guangdong 528200 [2]Department of Orthopedics, Linyi People's Hospital, Linyi, Shandong 276000 [3]Department of Substance Dependence, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, Guangdong 510370 [4]Physical Examination Center, The Second Traditional Chinese Medicine Hospital of Guangdong Provence, Guangzhou, Guangdong 510095 [5]Department of Microsurgery II, Wendeng Hospital of Traditional Chinese of Orthopedics and Traumatology of Shandong, Wendeng, Shandong 264400 [6]Department of Orthopedics, The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong 510405, P.R. China
出处：
DOI： 10.3892/ijmm.2018.3692
ISSN：

关键词： Bone marrow-derived mesenchymal stem cells New bone formation Rabbit femoral defect Transforming growth factor-β1

摘要：
Bone defects represent a major clinical and socioeconomic problem without suitable treatment options. Previous studies have shown that transforming growth factor β1 (TGF-β1) is important in the development of various diseases. The present study aimed to investigate the therapeutic potential of rabbit bone marrow-derived mesenchymal stem cells (BMSCs) expressing TGF-β1 in the treatment of rabbit femoral defects. First, rabbit BMSCs were identified and cultured. TGF-β1 was then stably overexpressed in the rabbit BMSCs by lentivirus transfection, which was expressed at a high level in the femoral defects treated with TGF-β1-overexpressing BMSCs, compared with PBS-treated controls. In addition, the TGF-β1-overexpressing BMSCs promoted new bone formation in the rabbit femoral defect model, and increased the expression of bone-related markers at week 2 and week 6. Therefore, the study demonstrated that BMSCs overexpressing TGF-β1 may provide a novel therapeutic option for femoral defects. © 2018 Spandidos Publications. All rights reserved.

基金：
This study was supported by Shandong Provincial Natural Science Foundation (grant no. BS2014YY026) and the Foshan Municipal Health Bureau for Scientific Research (grant nos. 20170161 and 20180184).
语种：
外文
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中科院(CAS)分区：
出版当年[2017]版：
大类 | 3 区 医学
小类 | 4 区 医学：研究与实验
最新[2025]版：
大类 | 2 区 医学
小类 | 2 区 医学：研究与实验
JCR分区：
出版当年[2016]版：
Q3 MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q1 MEDICINE, RESEARCH & EXPERIMENTAL

影响因子： 最新[2023版] 最新五年平均 出版当年[2016版] 出版当年五年平均 出版前一年[2015版] 出版后一年[2017版]

第一作者：
第一作者机构： [1]Department of Orthopedics, Shunde Hospital of Guangzhou University of Chinese Medicine, Foshan, Guangdong 528200
共同第一作者：
通讯作者：
通讯机构： [6]Department of Orthopedics, The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong 510405, P.R. China [*1]Department of Orthopedics, The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, 16 Jichang Road, Guangzhou, Guangdong 510405, P.R. China
推荐引用方式(GB/T 7714)：
Bing‑Yin Sun,Bao‑Xiang Zhao,Jie‑Ying Zhu,et al.Role of TGF‑β1 expressed in bone marrow‑derived mesenchymal stem cells in promoting bone formation in a rabbit femoral defect model(Open Access)[J].INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE.2018,42(2):897-904.doi:10.3892/ijmm.2018.3692.
APA：
Bing‑Yin Sun,Bao‑Xiang Zhao,Jie‑Ying Zhu,Zheng‑Ping Sun,Yong‑An Shi&Feng Huang.(2018).Role of TGF‑β1 expressed in bone marrow‑derived mesenchymal stem cells in promoting bone formation in a rabbit femoral defect model(Open Access).INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,42,(2)
MLA：
Bing‑Yin Sun,et al."Role of TGF‑β1 expressed in bone marrow‑derived mesenchymal stem cells in promoting bone formation in a rabbit femoral defect model(Open Access)".INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 42..2(2018):897-904

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