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Endoplasmic reticulum stress drives macrophages to produce IL-33 to favor Th2 polarization in the airways

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资源类型：
Pubmed体系：
作者：
Xiao Yuan[1] * ; Zhang Huangping[2] * ; Liu Yu[3] * ; Mo Lihua[3,4,5] ; Liao Yun[4,5] ; Huang Qinmiao[3] ; Yang Liteng[3] ; Zhou Caijie[6] ; Liu Jiangqi[5] ; Sun Xizhuo[3,*3] ; Yu Haiqiong[7,*2] ; Yang Pingchang[4,5,*1] ;
机构： [1]International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education, College of Pharmacy, Jinan University, Guangzhou 510632, China. [2]Department of Allergy Medicine, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan 030001, China. [3]Department of General Medicine and Respirology, Third Affiliated Hospital of Shenzhen University, Shenzhen 518055, China. [4]Guangdong Provincial Regional Disease Key Laboratory, Shenzhen 518055, China. [5]Institute of Allergy and Immunology, State Key Laboratory of Respiratory Diseases Allergy Division at Shenzhen University, Shenzhen 518055, China. [6]Shenzhen Hospital, Beijing University of Chinese Medicine, Shenzhen 518016, China. [7]Department of Respiratory and Critical Care Medicine, The Eighth Affiliated Hospital of Sun Yat-Sen University, Shenzhen 518055, Guangdong, China.
出处：
DOI： 10.1093/jleuko/qiad109
ISSN：

关键词： asthma endoplasmic reticulum stress immunity IL-33 macrophage

摘要：
Interleukin (IL)-33 is a key driver of T helper 2 (Th2) cell polarization. Endoplasmic reticulum (ER) stress plays a role in the skewed T cell activation. The objective of this project is to elucidate the role of IL-33 derived from macrophages in inducing Th2 polarization in the airways. In this study, bronchoalveolar lavage fluids (BALF) were collected from patients with asthma and healthy control subjects. Macrophages were isolated from the BALF by flow cytometry cell sorting. An asthmatic mouse model was established using the ovalbumin/alum protocol. The results showed that increased IL33 gene activity and ER stress-related molecules in BALF-derived M2a macrophages was observed in asthmatic patients. Levels of IL33 gene activity in M2a cells were positively correlated with levels of asthma response in asthma patients. Sensitization exacerbated the ER stress in the airway macrophages, which increased the expression of IL-33 in macrophages of airway in sensitized mice. Conditional ablation of Il33 or Perk or Atf4 genes in macrophages prevented induction of airway allergy in mice. In conclusion, asthma airway macrophages express high levels of IL-33 and at high ER stress status. Inhibition of IL-33 or ER stress in macrophages can effectively alleviate experimental asthma.© The Author(s) 2024. Published by Oxford University Press on behalf of Society for Leukocyte Biology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.

基金：
This study was supported by research grants of the National Natural Science Foundation of China (32090052); Guangdong Provincial Key Laboratory of Regional Immunity and Diseases (2019B030301009); Guangdong Natural Science Foundation (2021A1515011535); and Shenzhen Science, Technology, and Shenzhen Longgang Scientific Innovation Funds (LGKCYLWS2022032) and innovation committee (KQTD20170331 145453160, SGDX20201103095609027, JCYJ20220531091417040).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 3 区 医学
小类 | 3 区 血液学 4 区 细胞生物学 4 区 免疫学
最新[2025]版：
大类 | 4 区 医学
小类 | 4 区 细胞生物学 4 区 血液学 4 区 免疫学
第一作者：
第一作者机构： [1]International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education, College of Pharmacy, Jinan University, Guangzhou 510632, China.
共同第一作者：
通讯作者：
通讯机构： [3]Department of General Medicine and Respirology, Third Affiliated Hospital of Shenzhen University, Shenzhen 518055, China. [4]Guangdong Provincial Regional Disease Key Laboratory, Shenzhen 518055, China. [5]Institute of Allergy and Immunology, State Key Laboratory of Respiratory Diseases Allergy Division at Shenzhen University, Shenzhen 518055, China. [7]Department of Respiratory and Critical Care Medicine, The Eighth Affiliated Hospital of Sun Yat-Sen University, Shenzhen 518055, Guangdong, China. [*1]Room A7-509 of Lihu Campus of Shenzhen University, 1066 Xueyuan Blvd, Shenzhen 518055, China [*2]Department of Respiratory and Critical Care Medicine, The Eighth Affiliated Hospital of Sun Yat-Sen University, Shenzhen, Guangdong 518033,China. [*3]Department of General Medicine and Respirology, Third Affiliated Hospital of Shenzhen University,Shenzhen 518055, China
推荐引用方式(GB/T 7714)：
Xiao Yuan,Zhang Huangping,Liu Yu,et al.Endoplasmic reticulum stress drives macrophages to produce IL-33 to favor Th2 polarization in the airways[J].Journal Of Leukocyte Biology.2024,doi:10.1093/jleuko/qiad109.
APA：
Xiao Yuan,Zhang Huangping,Liu Yu,Mo Lihua,Liao Yun...&Yang Pingchang.(2024).Endoplasmic reticulum stress drives macrophages to produce IL-33 to favor Th2 polarization in the airways.Journal Of Leukocyte Biology,,
MLA：
Xiao Yuan,et al."Endoplasmic reticulum stress drives macrophages to produce IL-33 to favor Th2 polarization in the airways".Journal Of Leukocyte Biology .(2024)

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