机构：[1]Second School of Clinical Medicine, Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine广东省中医院[2]Department of Orthopaedics, Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine大德路总院骨科广东省中医院[3]Department of Traditional Chinese Medicine, GuangDong Women and Children Hospital, China.
Background: Knee osteoarthritis (KOA) is one of the most common chronic muscular diseases in old people. The purpose of this meta-analysis was to compare celecoxib and diclofenac sodium in patients with knee osteoarthritis (KOA). Methods: Randomized controlled trials (RCTs) and clinical controlled trials (CCTs) comparing the use of celecoxib and diclofenac sodium in KOA patients were retrieved from each database from the date of database inception to September 2019. The outcome measurements were the treatment effect, visual analog scale (VAS) score, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) level, and complication rate. The pooled data were evaluated with Review Manager 5.3.5. Results: The literature will provide a high-quality analysis of the current evidence supporting celecoxib for KOA based on various comprehensive assessments including the treatment effect, visual analog scale (VAS) score, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) level, and complication rate. Conclusion: This proposed systematic review will provide up-to-date evidence to assess the effect of celecoxib in the treatment for patients with KOA.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81873314, 81974574]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2018M633036]; Medical Science Research Foundation of Guangdong Province [B2019091]; Project of Guangdong Provincial Department of Finance [[2014]157, [2018]8]; Key scientific research platforms and research projects of universities in Guangdong Province [2018KQNCX041]; Science and Technology Research Project of Guangdong Provincial Hospital of Chinese Medicine [YN2019ML08, YK2013B2N19, YN2015MS15]; Excellent Doctoral Dissertation Training Program of Guangzhou University of Chinese Medicine
第一作者机构：[1]Second School of Clinical Medicine, Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine
通讯作者：
通讯机构：[2]Department of Orthopaedics, Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine[3]Department of Traditional Chinese Medicine, GuangDong Women and Children Hospital, China.[*1]Department of Traditional Chinese Medicine, GuangDong Women and Children Hospital, Guangzhou, 511400 China[*2]Department of Orthopaedics, Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, 510120 China
推荐引用方式(GB/T 7714)：
Huang Hetao,Pan Jianke,Yang Weiyi,et al.Celecoxib vs diclofenac sodium in patients with knee osteoarthritis A protocol for systematic review and meta analysis[J].MEDICINE.2020,99(15):doi:10.1097/MD.0000000000019680.
APA：
Huang, Hetao,Pan, Jianke,Yang, Weiyi,Chen, Hongyun,Liang, Guihong...&Pan, Biqi.(2020).Celecoxib vs diclofenac sodium in patients with knee osteoarthritis A protocol for systematic review and meta analysis.MEDICINE,99,(15)
MLA：
Huang, Hetao,et al."Celecoxib vs diclofenac sodium in patients with knee osteoarthritis A protocol for systematic review and meta analysis".MEDICINE 99..15(2020)
