机构：[1]Department of Gastroenterology, Changhai Hospital, TheSecond Military University, Shanghai, China[2]Department of Gastroenterology, The Fifth Medical Centre,Chinese PLA General Hospital (Former 307th Hospitalof the PLA), Beijing, China[3]Endoscopy Center, Shanxi Cancer Hospital, Taiyuan, China[4]Department of Gastroenterology, Affiliated Hangzhou FirstPeople’s Hospital, Zhejiang University School of Medicine,Hangzhou, China[5]Jiangsu Province Hospital of TCM and Affiliated Hospitalof Nanjing University of TCM, Nanjing, China江苏省人民医院[6]The First Affiliated Hospital of Anhui Medical University,Hefei, China[7]The First Affiliated Hospital of Nanchang University,Nanchang, China[8]Department of Gastroenterology, Zhongshan HospitalAffiliated to Xiamen University, Xiamen, China[9]Chongqing Key Laboratory of Translational Researchfor Cancer Metastasis and Individualized Treatment,Chongqing University Cancer Hospital and ChongqingCancer Institute and Chongqing Cancer Hospital, Chongqing,China[10]Affiliated Hospital of Guilin Medical University, Guilin,China[11]Guangdong Provincial TCM Hospital, Guangzhou, China[12]Gastroenterology Department of Xiangya Hospital, CSU,Changsha, China[13]Zhongnan Hospital of Wuhan University, Wuhan, China[14]Xi’an Central Hospital, Xi’an, China[15]Digestive Endoscopy Center, Changhai Hospital, The SecondMilitary University, Shanghai, China
Background Early diagnosis of gastric cancer is difficult in China due to the lack of a valid method for endoscopic screening. Early gastric cancer, especially flat gastric cancer, lacks specific endoscopic features. Many cases appear to be similar to ordinary gastritis cases under normal white light endoscopy, which can lead to misdiagnosis. Aims In order to find a new method to improve detection rate of early gastric cancer in China, we designed a trial to validate linked color imaging (LCI) for screening of early gastric cancer in a high-risk population, as compared to white light imaging (WLI). Method Subjects were randomly allocated to either the LCI + WLI or WLI group and then subjected to gastroscopy and all endoscopies were made after special preparation. All endoscopists had knowledge of this experiment. The main indicator was the rate of detection of gastric neoplastic lesions. The difference in the detection rate between the two groups is reported. Results The detection rate was 4.31% in the WLI group and 8.01% in the LCI + WLI group. This is a difference of 3.70% with a P value < 0.001 and an OR (95% CI) of 1.934 (1.362, 2.746). The lower limit of the 95% CI was greater than 0, and the superiority margin was 1%. Conclusion The detection rate of gastric neoplastic lesions was higher in the LCI + WLI group than in the WLI group, LCI might be an effective method for screening early gastric cancer.
第一作者机构：[1]Department of Gastroenterology, Changhai Hospital, TheSecond Military University, Shanghai, China
通讯作者：
通讯机构：[1]Department of Gastroenterology, Changhai Hospital, TheSecond Military University, Shanghai, China[15]Digestive Endoscopy Center, Changhai Hospital, The SecondMilitary University, Shanghai, China
推荐引用方式(GB/T 7714)：
Jie Gao,Xiaofeng Zhang,Qianqian Meng,et al.Linked Color Imaging Can Improve Detection Rate of Early Gastric Cancer in a High-Risk Population: A Multi-Center Randomized Controlled Clinical Trial[J].DIGESTIVE DISEASES AND SCIENCES.2021,66(4):1212-1219.doi:10.1007/s10620-020-06289-0.
APA：
Jie Gao,Xiaofeng Zhang,Qianqian Meng,Hangbin Jin,Zhenhua Zhu...&Dong Wang.(2021).Linked Color Imaging Can Improve Detection Rate of Early Gastric Cancer in a High-Risk Population: A Multi-Center Randomized Controlled Clinical Trial.DIGESTIVE DISEASES AND SCIENCES,66,(4)
MLA：
Jie Gao,et al."Linked Color Imaging Can Improve Detection Rate of Early Gastric Cancer in a High-Risk Population: A Multi-Center Randomized Controlled Clinical Trial".DIGESTIVE DISEASES AND SCIENCES 66..4(2021):1212-1219
