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NLRP3 inflammasomes in macrophages drive colorectal cancer metastasis to the liver

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收录情况： ◇ SCIE

作者：
Deng, Qiaoting[1,7] * ; Geng, Yan[2] * ; Zhao, Liying[3] * ; Li, Ru[1] ; Zhang, Zhigao[1] ; Li, Kun[1] ; Liang, Rongliang[4] ; Shao, Xiangyang[1] ; Huang, Maoliang[5] ; Zuo, Daming[6] ; Wu, Yingsong[1] ; Ma, Qiang[1] ;
机构： [1]Institute of Antibody Engineering, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, Guangdong, PR China [2]Department of Gastroenterology, 303 Hospital of People's Liberation Army, Nanning 530021, PR China [3]Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, PR China [4]Department of Laboratory Science, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong province, 510120, China [5]Fuzhou Dingxiang Clinic, Fuzhou, Fujian 350028 China [6]Institute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, Guangdong, PR China [7]Clinical Core Laboratory, Center for Precision Medicine, Meizhou People's Hospital (Huangtang Hospital), Merzhou Hospital Affiliated to Sun Yat-sen University, Meizhou 514031, PR China
出处：
DOI： 10.1016/j.canlet.2018.10.030
ISSN：

关键词： NLRP3 inflammasome Macrophage Tumor microenvironment Colorectal cancer Liver metastasis

摘要：
Inflammation and immunity are important determinants of cancer initiation, promotion, and progression to cancer equilibrium or suppression. The NOD-like receptor family pyrin domain containing 3 (NLRP3) is an oligomeric intracellular immune receptor, and the main component of inflammasome. As a widely distributed effector of innate immunity, NLRP3 inflammasome affects development of many cancer types, but its exact role in colorectal cancer (CRC) is controversial. We found that cells with the macrophage (M Phi) marker CD68 and strong NLRP3 expression densely surrounded CRC tissue. The NLRP3 inflammasome was activated in M Phi s by M Phi-CRC cell crosstalk; it resulted in faster migration of CRC cells, whereas blocking NLRP3 signaling suppressed CRC cell migration in vitro, and metastatic ability in vivo. NLRP3 signaling activation in M Phi s can contribute to CRC cell migration and invasion.

基金：
National Natural Science Foundation of China [81772133 and 81741133]; Guangdong Natural Science Fund of China [2016A030313529], and Outstanding Young Teachers Training Program of China [YQ2015037]; Guangxi Natural Science Fund 2017GXNSFDA198051 and 2016GXNSFAA380313.
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外文
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中科院(CAS)分区：
出版当年[2018]版：
大类 | 1 区 医学
小类 | 2 区 肿瘤学
最新[2025]版：
大类 | 1 区 医学
小类 | 2 区 肿瘤学
JCR分区：
出版当年[2017]版：
Q1 ONCOLOGY
最新[2023]版：
Q1 ONCOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2017版] 出版当年五年平均 出版前一年[2016版] 出版后一年[2018版]

第一作者：
第一作者机构： [1]Institute of Antibody Engineering, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, Guangdong, PR China [7]Clinical Core Laboratory, Center for Precision Medicine, Meizhou People's Hospital (Huangtang Hospital), Merzhou Hospital Affiliated to Sun Yat-sen University, Meizhou 514031, PR China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Deng Qiaoting,Geng Yan,Zhao Liying,et al.NLRP3 inflammasomes in macrophages drive colorectal cancer metastasis to the liver[J].CANCER LETTERS.2019,442:21-30.doi:10.1016/j.canlet.2018.10.030.
APA：
Deng, Qiaoting,Geng, Yan,Zhao, Liying,Li, Ru,Zhang, Zhigao...&Ma, Qiang.(2019).NLRP3 inflammasomes in macrophages drive colorectal cancer metastasis to the liver.CANCER LETTERS,442,
MLA：
Deng, Qiaoting,et al."NLRP3 inflammasomes in macrophages drive colorectal cancer metastasis to the liver".CANCER LETTERS 442.(2019):21-30

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