机构：[1]Stroke Biological Recovery Laboratory, Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, theteaching affiliate of Harvard Medical School,Charlestown, MA 02129, USA[2]Department of Acupuncture and Moxibustion, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518033, Guangdong, China深圳市康宁医院深圳医学信息中心[3]Jiangsu Provincial Key Laboratory for Interventional Medical Devices, Huaiyin Institute of Technology, Huai’an 223003, Jiangsu,China[4]Department of Microbiology, Biochemistry and Molecular Genetics,New Jersey Medical School, Rutgers, The State University of NewJersey, Newark, NJ 07103, USA[5]Department of Rehabilitation Medicine, The Third Affiliated Hospital, Sun Yat-sen University, 600 Tianhe Road,Guangzhou 510630, Guangdong, China中山大学附属第三医院[6]Department of Physical medicine and Rehabilitation, Shengjing Hospital, China Medical University, Shenyang 110003, Liaoning,China中国医科大学附属盛京医院[7]Departments of Physical Medicine & Rehabilitation, Harvard Medical School/Spaulding Rehabilitation Hospital Network,Brigham and Women’s Hospital, and Massachusetts General Hospital, Boston, MA, USA[8]Kerry Rehabilitation Medicine Research Institute,Shenzhen 518048, Guangdong, China[9]Shenzhen Sanming Project Group, Spaulding Rehabilitation Hospital, the teaching affiliate of Harvard Medical School,Charlestown, MA 02129, USA[10]School of Nursing, MGH Institute of Health Professions,Charlestown, MA 02129, USA[11]The First Affiliated Hospital of Shenzhen University, Shenzhen Second People’s Hospital, Shenzhen 518035, Guangdong, China深圳市第二人民医院深圳医学信息中心
Brain-derived neurotrophic factor (BDNF) plays an important role in neuroplasticity and neurogenesis following ischemic and non-ischemic brain injury. The predictive value of BDNF for short-term outcome after stroke is controversial. The objective of this study was to investigate the relationship among serum BDNF level, fractional anisotropy (FA), and functional outcome during post-acute stroke rehabilitation. Serum BDNF levels were measured on admission to an acute inpatient rehabilitation hospital. The primary functional outcome was functional independence measure (FIM) motor subscore at discharge. The secondary outcome measures were FIM total score at discharge, FIM motor subscore on admission, length of stay in the hospital, and discharge destination. We investigated the relationship among the level of serum BDNF and FA as well as functional outcome measures. Three hundred forty-eight consecutive stroke subjects were included in the analysis. Serum BDNF levels on admission were statistically but not clinically correlated with FIM motor subscore at discharge (r=0.173, P=0.001) and FIM total score at discharge (r=0.155, P=0.004). Receiver operating characteristic (ROC) analysis of BDNF as a predictor for FIM motor subscore improvement showed low accuracy of prediction with an area under the curve (AUC) of 0.581 (P=0.026). Serum BDNF significantly correlated with FA in the high FIM motor group (n=10, r=0.609, P=0.031) but not in the low FIM motor group (n=11, r=-0.132, P=0.349). The serum BDNF level alone offers minimum predictive value for recovery of motor function during post-acute rehabilitation. Our findings suggest that serum BDNF level may be correlated with FA.
基金：
Harvard Catalyst/The Harvard Clinical and Translational Science Center (National Center for Research Resources); Harvard Catalyst/The Harvard Clinical and Translational Science Center (National Center for Advancing Translational Sciences, National Institutes of Health) [UL1 TR001102]; Harvard University and its affiliated academic health care centers; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [12ykpy39]; Shenzhen "Sanming project" [SZSM201610039]
第一作者机构：[1]Stroke Biological Recovery Laboratory, Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, theteaching affiliate of Harvard Medical School,Charlestown, MA 02129, USA[2]Department of Acupuncture and Moxibustion, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518033, Guangdong, China
共同第一作者：
通讯作者：
通讯机构：[1]Stroke Biological Recovery Laboratory, Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, theteaching affiliate of Harvard Medical School,Charlestown, MA 02129, USA[7]Departments of Physical Medicine & Rehabilitation, Harvard Medical School/Spaulding Rehabilitation Hospital Network,Brigham and Women’s Hospital, and Massachusetts General Hospital, Boston, MA, USA
推荐引用方式(GB/T 7714)：
Luo Wenshu,Liu Tao,Li Shanshan,et al.The Serum BDNF Level Offers Minimum Predictive Value for Motor Function Recovery After Stroke[J].TRANSLATIONAL STROKE RESEARCH.2019,10(4):342-351.doi:10.1007/s12975-018-0648-5.
APA：
Luo, Wenshu,Liu, Tao,Li, Shanshan,Wen, Hongmei,Zhou, Fenghua...&Wang, Qing Mei.(2019).The Serum BDNF Level Offers Minimum Predictive Value for Motor Function Recovery After Stroke.TRANSLATIONAL STROKE RESEARCH,10,(4)
MLA：
Luo, Wenshu,et al."The Serum BDNF Level Offers Minimum Predictive Value for Motor Function Recovery After Stroke".TRANSLATIONAL STROKE RESEARCH 10..4(2019):342-351
医学