机构：[1]Department of Laboratory Animals, College of Animal Sciences, JiLinUniversity in Changchun of Jilin Province in China, Xian Road 5333#,Changchun 130062, China[2]Guangdong Provincial Hospital of ChineseMedicine-Zhuhai Hospital, Zhuhai 519015, China[3]China-Japan UnionHospital of Jilin University, Changchun 130333, China吉林大学中日联谊医院[4]College of AnimalScience and Technology, Jilin Agricultural University, Changchun 130118,China[5]Department of Immunology, School of Basic Medical Sciences, FudanUniversity, Shanghai 200032, China[6]The 2nd Clinical School of Medicine,Guangdong Provincial Hospital of Chinese Medicine, Guangzhou Universityof Chinese Medicine, Guangzhou 510120, China广东省中医院[7]The 85th Hospital of CPLA,Shanghai 200040, China
Breast cancer is a heterogeneous disease with increasing incidence and mortality and represents one of the most common cancer types worldwide. Low-density lipoprotein (LDL) is a complex particle composed of several proteins and lipids, which carries cholesterol into peripheral tissues and also affects the metabolism of fatty acids. Recent reports have indicated an emerging role of LDL in breast cancer, affecting cell proliferation and migration, thereby facilitating disease progression. However, controversy still exists among distinct types of breast cancer that can be affected by LDL. Classical therapeutic approaches, such as radiotherapy, chemotherapy, and lipid-lowering drugs were also reported as affecting LDL metabolism and content in breast cancer patients. Therefore, in this review we summarized and discussed the role of LDL in the development and treatment of breast cancer.
基金：
National Natural Science Foundation of
China (No. 81603460, to QL), Postdoctoral Science Foundation of China (No.
2015 M581533, to QL); and Jilin Province Science and Technology
Development Project (No. 20170623033TC, 20170623035TC, to YD).
第一作者机构：[1]Department of Laboratory Animals, College of Animal Sciences, JiLinUniversity in Changchun of Jilin Province in China, Xian Road 5333#,Changchun 130062, China
共同第一作者：
通讯作者：
通讯机构：[2]Guangdong Provincial Hospital of ChineseMedicine-Zhuhai Hospital, Zhuhai 519015, China[5]Department of Immunology, School of Basic Medical Sciences, FudanUniversity, Shanghai 200032, China[6]The 2nd Clinical School of Medicine,Guangdong Provincial Hospital of Chinese Medicine, Guangzhou Universityof Chinese Medicine, Guangzhou 510120, China
推荐引用方式(GB/T 7714)：
Guan Xuefeng,Liu Zhuo,Zhao Zhen,et al.Emerging roles of low-density lipoprotein in the development and treatment of breast cancer[J].LIPIDS IN HEALTH AND DISEASE.2019,18:doi:10.1186/s12944-019-1075-7.
APA：
Guan, Xuefeng,Liu, Zhuo,Zhao, Zhen,Zhang, Xuefeng,Tao, Siteng...&Ding, Yu.(2019).Emerging roles of low-density lipoprotein in the development and treatment of breast cancer.LIPIDS IN HEALTH AND DISEASE,18,
MLA：
Guan, Xuefeng,et al."Emerging roles of low-density lipoprotein in the development and treatment of breast cancer".LIPIDS IN HEALTH AND DISEASE 18.(2019)
