机构：[1]Institute of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China[2]School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China[3]Guangdong Key Laboratory of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou 510006, China[4]Orthopedics Department, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, China广东省中医院深圳市中医院深圳医学信息中心[5]Department of Nuclear Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, China广东省中医院
Imitating the physiological microenvironment of living cell and tissues opens new avenues of research into the application of electricity to medical therapies. In this study, dynamic piezoelectric stimulation is generated in a dynamic culture because of the piezoelectric effect of the poly(vinylidene fluoride)-polypyrrole (PVDF-PPy) electroactive composite. Combined with PPy nanocones, dynamic piezoelectric signals are effectively and continuously provided to cells. In the presence of dynamic piezoelectric stimulation and PPy nanocones, PPy-PVDF NS samples show promoted bone mesenchymal stem cell (BMSCs) adhesion, spreadin, and osteogenic differentiation. On the basis of the results of this study, PPy nanocones and dynamic piezoelectric stimulation can be administered to modulate cell behavior, paving the way for the exploration of cellular responses to dynamic electrical stimulation.
基金：
the National Natural Science
Foundation of China (grant nos. 51772106, 51702104, and
31771080), the Natural Science Foundation of Guangdong
Province (grant no. 2016A030308014), the Technological
Projects of Guangzhou, China (grant no. 201604020110), and
the China Postdoctoral Science Foundation (grant no.
2017M622641)
第一作者机构：[1]Institute of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China
通讯作者：
通讯机构：[2]School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China[3]Guangdong Key Laboratory of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou 510006, China
