Altered Intra- and Inter-regional Functional Connectivity of the Anterior Cingulate Gyrus in Patients With Tremor-Dominant Parkinson's Disease Complicated With Sleep Disorder
机构：[1]The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China,广东省中医院[2]Department of Radiology, Guangdong Hospital of Traditional Chinese Medicine, Guangzhou, China,大德路总院影像科大德路总院放射科广东省中医院[3]Department of Radiology, ZHUHAI Branch of Guangdong Hospital of Traditional Chinese Medicine, Zhuhai, China大德路总院珠海院区影像科影像科大德路总院放射科珠海影像科广东省中医院
Objective: To investigate changes in brain function at the regional and whole-brain levels in patients with tremor-dominant Parkinson's disease (TDPD) complicated by sleep disorder (SD) by regional homogeneity (ReHo) and functional connectivity (FC) analysis of whole-brain resting-state functional magnetic resonance images. Materials and Methods: ReHo and seed-based FC analyses were conducted among 32 patients with TDPD and SD (TDPD-SD), 24 with TDPD and no SD (TDPD-NSD), and 23 healthy controls (HCs) to assess spontaneous brain activity and network-level brain function. Correlation analyses were used to examine the associations between brain activity and the clinical data. Results: Anterior cingulate gyrus (ACC) ReHo values differed significantly among the groups. ACC ReHo values were increased in TDPD-SD vs. HC and TDPD-SD vs. TDPD-NSD. ACC ReHo values were reduced in TDPD-NSD vs. HC. TDPD-SD ReHo values were positively correlated with Pittsburgh Sleep Quality Index (PSQI) scores (r = 0.41, p = 0.020) but negatively correlated with Parkinson's Disease Sleep Scale (PDSS) scores (r = -0.38, p = 0.030). FC analysis using ACC as a mask showed that FC of the left olfactory cortex (L-OC), right straight gyrus (R-SG), right superior parietal gyrus (R-SPG), and right precuneus differed significantly among the groups. FC values between R-SG and ACC were significantly lower in TDPD-SD than in TDPD-NSD, while the FC of L-OC and R-OC with ACC was significantly lower in TDPD-SD than in HC. FC between ACC and L-OC, R-SPG, and the right precuneus was lower in TDPD-NSD than in HC. There was no correlation between the FC values and other clinical data in any of the groups. Conclusion: Localized abnormal activity in TDPD-SD was chiefly triggered by ACC. The change in the ReHo of ACC is closely related to the severity of TDPD-associated SD, revealing the role of this region as a regulator of the sleep mechanism in TDPD. Significant abnormal FC was found between R-SG and ACC in TDPD-SD but was not shown to correlate with clinical data.
基金：
National Natural Science
Foundation of China (Grant number 81603681) and the
Special Fund of Traditional Chinese Medicine Hospital of
Guangdong Province (Grant number 2015QN18) and Science
and Technology Planning Project of Guangdong Province, China
(Grant number: 2016A020215201).
第一作者机构：[1]The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China,
共同第一作者：
通讯作者：
通讯机构：[1]The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China,[3]Department of Radiology, ZHUHAI Branch of Guangdong Hospital of Traditional Chinese Medicine, Zhuhai, China
推荐引用方式(GB/T 7714)：
Chen Xinjie,Hou Xiaoyan,Luo Xiaodong,et al.Altered Intra- and Inter-regional Functional Connectivity of the Anterior Cingulate Gyrus in Patients With Tremor-Dominant Parkinson's Disease Complicated With Sleep Disorder[J].FRONTIERS IN AGING NEUROSCIENCE.2019,11:doi:10.3389/fnagi.2019.00319.
APA：
Chen, Xinjie,Hou, Xiaoyan,Luo, Xiaodong,Zhou, Sifan,Liu, Xian...&Chen, Jun.(2019).Altered Intra- and Inter-regional Functional Connectivity of the Anterior Cingulate Gyrus in Patients With Tremor-Dominant Parkinson's Disease Complicated With Sleep Disorder.FRONTIERS IN AGING NEUROSCIENCE,11,
MLA：
Chen, Xinjie,et al."Altered Intra- and Inter-regional Functional Connectivity of the Anterior Cingulate Gyrus in Patients With Tremor-Dominant Parkinson's Disease Complicated With Sleep Disorder".FRONTIERS IN AGING NEUROSCIENCE 11.(2019)
