Promoter Variation and Gene Expression of mcr-1-Harboring Plasmids in Clinical Isolates of Escherichia coli and Klebsiella pneumoniae from a Chinese Hospital
机构：[1]Department of Laboratory Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China中山大学附属第一医院[2]Department of Laboratory Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China大德路总院检验科大德路总院检验科广东省中医院[3]Department of Laboratory Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China大德路总院检验科大德路总院检验科广东省中医院[4]Department of Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA[5]Public Health Research Institute Tuberculosis Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA
Next-generation sequencing of 6 mcr-1-harboring Escherichia coli and Klebsiella pneumoniae isolates collected from a tertiary care hospital in China revealed significant sequence variations in the regions flanking the mcr-1 gene. While sequence variations significantly affected the expression and promoter activity of mcr-1, the mcr-1 gene expression levels did not correlate with the in vitro colistin resistance levels, which warrants further in-depth investigations.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81572058, 81672081, 81772249]; Guangdong Natural Science FoundationNational Natural Science Foundation of Guangdong Province [2014A030313143]; State Education Ministry Scientific Research Foundation for the Returned Overseas Chinese ScholarsScientific Research Foundation for the Returned Overseas Chinese Scholars; National Institute of Allergy and Infectious DiseasesUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Allergy & Infectious Diseases (NIAID) [R01AI090155, R21AI117338]
第一作者机构：[1]Department of Laboratory Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
共同第一作者：
通讯作者：
通讯机构：[2]Department of Laboratory Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China[3]Department of Laboratory Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China
推荐引用方式(GB/T 7714)：
Huang Bin,He Yuting,Ma Xingyan,et al.Promoter Variation and Gene Expression of mcr-1-Harboring Plasmids in Clinical Isolates of Escherichia coli and Klebsiella pneumoniae from a Chinese Hospital[J].ANTIMICROBIAL AGENTS AND CHEMOTHERAPY.2018,62(5):doi:10.1128/AAC.00018-18.
APA：
Huang, Bin,He, Yuting,Ma, Xingyan,Cai, Renxin,Zeng, Jianming...&Chen, Liang.(2018).Promoter Variation and Gene Expression of mcr-1-Harboring Plasmids in Clinical Isolates of Escherichia coli and Klebsiella pneumoniae from a Chinese Hospital.ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,62,(5)
MLA：
Huang, Bin,et al."Promoter Variation and Gene Expression of mcr-1-Harboring Plasmids in Clinical Isolates of Escherichia coli and Klebsiella pneumoniae from a Chinese Hospital".ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 62..5(2018)
医学