机构：[1]Department of Integrated Traditional and Western Medicine, The Third Affiliated Hospital of SunYat-sen University, Guangzhou, P.R. China中山大学附属第三医院[2]Department of Oncology Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, P.R. China大德路总院肿瘤科广东省中医院[3]Department of Hepatobiliary Surgery, The Third Affiliated Hospital of SunYat-sen University, Guangzhou, P.R. China中山大学附属第三医院[4]Department of Acupuncture, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, P.R. China大德路总院针灸科大德路总院针灸科广东省中医院[5]Department of Infertility and Sterility, Guangdong Provincial Family Planning Research Institute, Guangzhou, P.R. China
The direct roles of miR-139-3p on hepatocellular carcinoma (HCC) cell growth and metastasis remain poorly understood. We attempted to demonstrate the regulatory role of miR-139-3p in HCC progression and its underlying mechanisms. Here we showed that miR-139-3p expression was significantly reduced in the HCC tissues compared to paratumor tissues. Exogenous overexpression of miR-139-3p inhibited the migration and invasion of HCC cells, whereas downregulation of miR-139-3p was able to induce HCC HepG2 and SNU-449 cell migration and invasion. In addition, miR-139-3p inhibited HCC growth and lung metastasis in an in vivo mouse model, which is mainly regulated by annexin A2 receptor (ANXA2R). Finally, we identified that the expression of miR-139-3p was inversely correlated with ANXA2R expression in human HCC tissue. All these results demonstrated that miR-139-3p inhibited the metastasis process in HCC by downregulating ANXA2R expression.
第一作者机构：[1]Department of Integrated Traditional and Western Medicine, The Third Affiliated Hospital of SunYat-sen University, Guangzhou, P.R. China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Integrated Traditional and Western Medicine, The Third Affiliated Hospital of SunYat-sen University, Guangzhou, P.R. China[*1]Department of Integrated Traditional and Western Medicine, The Third Affiliated Hospital of SunYat-sen University, No. 600 Tianhe Road, Tianhe District, Guangzhou 510630, P.R. China
推荐引用方式(GB/T 7714)：
Zou Zeng Cheng,Dai Min,Huang Zeng Yin,et al.MicroRNA-139-3p Suppresses Tumor Growth and Metastasis in Hepatocellular Carcinoma by Repressing ANXA2R[J].ONCOLOGY RESEARCH.2018,26(9):1391-1399.doi:10.3727/096504018X15178798885361.
APA：
Zou, Zeng Cheng,Dai, Min,Huang, Zeng Yin,Lu, Yi,Xie, He Ping...&Wang, Feng Lin.(2018).MicroRNA-139-3p Suppresses Tumor Growth and Metastasis in Hepatocellular Carcinoma by Repressing ANXA2R.ONCOLOGY RESEARCH,26,(9)
MLA：
Zou, Zeng Cheng,et al."MicroRNA-139-3p Suppresses Tumor Growth and Metastasis in Hepatocellular Carcinoma by Repressing ANXA2R".ONCOLOGY RESEARCH 26..9(2018):1391-1399
