机构：[1]Department of Ultrasonography, Guangdong Second Provincial General Hospital, Guangzhou, China[2]Paul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China[3]State Key Laboratory of High Performance Ceramic and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, China[4]Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Taiwan, China[5]School of Life Science and Engineering, Southwest University of Science and Technology, Mianyang, China[6]Department of Ultrasonography, Guangdong Provincial Hospital of Chinese Medicine, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China大德路总院影像科大德路总院超声影像科广东省中医院
Glioma is the most frequent primary brain tumour of the central nervous system. Its high aggressiveness and deep-seated brain lesion make it a great challenge to develop a non-invasive, precise and effective treatment approach. Here, we report a multifunctional theranostic agent that can integrate imaging and therapy into a single nano-platform for imaging-guided sonodynamic therapy (SDT). The SDT agents were fabricated by encapsulation of sinoporphyrin sodium (DVDMS) chelating with manganese ions into nanoliposomes (DVDMS-Mn-LPs). DVDMS-Mn-LPs are physiologically stable and biologically compatible, and they can produce singlet oxygen upon ultrasound irradiation to kill cancer cells. Both cell and animal studies demonstrated that SDT with DVDMS-Mn-LPs can significantly improve the antitumour growth efficiency even in the presence of skull. In addition, DVDMS-Mn-LPs are good for MR and fluorescence imaging. Thus, DVDMS-Mn-LPs reported here may provide a promising strategy for imaging-guided modality for glioma treatment.
基金：
National Key Basic Research Program of ChinaNational Basic Research Program of China [2015CB755500, 2014CB744502]; National Nature Science Foundation of ChinaNational Natural Science Foundation of China [81571764, 81571701, 81527901, 11534013, 81571745, 81401521, 81571674, 81771853]; Key Laboratory for Magnetic Resonance and Multimodality Imaging of Guangdong Province [2014B030301013]; Natural Science Foundation of Guangdong ProvinceNational Natural Science Foundation of Guangdong Province [2014A030313341, 2017A030313651, 2016A020213004, 2014A030312006]; National Key Research and Development Program of China [2016YFA0203700]; Shenzhen Science and Technology Innovation Committee [JCYJ20170307165254568, JCYJ20160229200902680]; Talent Research Foundation of Guangdong Second Provincial General Hospital [YN-2018-002]
第一作者机构：[1]Department of Ultrasonography, Guangdong Second Provincial General Hospital, Guangzhou, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Ultrasonography, Guangdong Second Provincial General Hospital, Guangzhou, China[2]Paul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China[*1]Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China
推荐引用方式(GB/T 7714)：
Liu Hongmei,Zhou Meijun,Sheng Zonghai,et al.Theranostic nanosensitizers for highly efficient MR/fluorescence imaging-guided sonodynamic therapy of gliomas[J].JOURNAL OF CELLULAR AND MOLECULAR MEDICINE.2018,22(11):5394-5405.doi:10.1111/jcmm.13811.
APA：
Liu, Hongmei,Zhou, Meijun,Sheng, Zonghai,Chen, Yu,Yeh, Chih-Kuang...&Zheng, Hairong.(2018).Theranostic nanosensitizers for highly efficient MR/fluorescence imaging-guided sonodynamic therapy of gliomas.JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,22,(11)
MLA：
Liu, Hongmei,et al."Theranostic nanosensitizers for highly efficient MR/fluorescence imaging-guided sonodynamic therapy of gliomas".JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 22..11(2018):5394-5405
