机构：[1]Stem Cell Research Center, College of Bee Science, Fujian Agriculture and Forestry University, 15 ShangXiaDian Rd, Fuzhou, Fujian 350002, China.[2]Center for Regenerative and Translational Medicine, The Second Affiliated Hospital (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou University of Chinese Medicine, 111 Dade Rd, Guangzhou, Guangdong 510120, China.大德路总院广东省中医院
The role of p53 as "a guardian of the genome" has been well established in somatic cells. However, its role in pluripotent stem cells remains much more elusive. Here, we discuss research progress in understanding the role of p53 in pluripotent stem cells and in pluripotent stem cell-like cancer stem cells. The p53 protein, which plays a key role in embryonic stem cells, was first discovered in 2005. Landmark studies of p53-related reprogramming elucidated this protein's importance in induced pluripotent stem cells in 2009. The p53-related safety concerns in pluripotent stem cells have been raised in stem cell-based therapy although the use of iPSCs in therapeutic application is promising. Because cancer stem cells have profiles similar to those of pluripotent stem cells, we also describe potential strategies for studies in cancer stem cells and cancer treatments. The new discoveries of p53 family proteins in pluripotent stem cells have made possible stable progress in stem cell transplantation efficiency and safety, as well as treatment strategies targeting cancer stem cells based on pluripotent stem cell technology.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [31271595]; Key Project of Chinese National Programs for Fundamental Research and Development (973 Programs)National Basic Research Program of China [2013CB9669002]; Science and Technology Department of Guangdong Province China [2015A020212032]; Guangdong Provincial Hospital of Chinese Medicine [YK2013B2N08]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2016]版：
大类|2 区医学
小类|2 区医学：研究与实验3 区细胞生物学
最新[2025]版：
大类|2 区医学
小类|2 区细胞与组织工程2 区细胞生物学2 区医学：研究与实验
JCR分区：
出版当年[2015]版：
Q1MEDICINE, RESEARCH & EXPERIMENTALQ2CELL BIOLOGY
最新[2023]版：
Q1CELL & TISSUE ENGINEERINGQ1CELL BIOLOGYQ1MEDICINE, RESEARCH & EXPERIMENTAL
第一作者机构：[1]Stem Cell Research Center, College of Bee Science, Fujian Agriculture and Forestry University, 15 ShangXiaDian Rd, Fuzhou, Fujian 350002, China.[2]Center for Regenerative and Translational Medicine, The Second Affiliated Hospital (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou University of Chinese Medicine, 111 Dade Rd, Guangzhou, Guangdong 510120, China.[*1]Stem Cell Research Center, College of Bee Science, Fujian Agriculture and Forestry University, 15 ShangXiaDian Rd, Fuzhou, Fujian 350002, China
共同第一作者：
通讯作者：
通讯机构：[1]Stem Cell Research Center, College of Bee Science, Fujian Agriculture and Forestry University, 15 ShangXiaDian Rd, Fuzhou, Fujian 350002, China.[2]Center for Regenerative and Translational Medicine, The Second Affiliated Hospital (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou University of Chinese Medicine, 111 Dade Rd, Guangzhou, Guangdong 510120, China.[*1]Stem Cell Research Center, College of Bee Science, Fujian Agriculture and Forestry University, 15 ShangXiaDian Rd, Fuzhou, Fujian 350002, China
推荐引用方式(GB/T 7714)：
Lin Tongxiang,Lin Yi.p53 switches off pluripotency on differentiation[J].STEM CELL RESEARCH & THERAPY.2017,8:doi:10.1186/s13287-017-0498-1.
APA：
Lin, Tongxiang&Lin, Yi.(2017).p53 switches off pluripotency on differentiation.STEM CELL RESEARCH & THERAPY,8,
MLA：
Lin, Tongxiang,et al."p53 switches off pluripotency on differentiation".STEM CELL RESEARCH & THERAPY 8.(2017)
医学