机构：[1]School of Chinese Materia medica, Guangzhou University of Chinese Medicine, Guangzhou, China[2]School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China[3]Second affiliation hospital, Guangzhou University of Chinese Medicine, Guangzhou, China
Two new triterpenes and five new triterpene saponins, named ilexpusons A-G (1-7), as well as eight known compounds were isolated from Ilex pubescens. The structures of the new compounds were established by a combination of chemical and spectroscopic methods, including HRESIMS, 1H-NMR, 13C-NMR, 1H-1H COSY, HSQC, HMBC, and NOESY. Additionally, the biological activity of compounds 1-15 against adenosine diphosphate-induced platelet aggregation in rabbit plasma was determined. Among the tested compounds, 1, 2, 5, 6, 8, 13, 14, and 15 exhibited significant inhibition of platelet aggregation in vitro.
基金：
National Natural Science Foundation of China [81673565, 81270054]; program for Outstanding Young Teachers in Higher Education Institutions of Guangdong Province [Yq2013045]; Science and Technology Planning Project of Guangdong Province [2016A020226031]; Guangzhou Science Technology and Innovation Commission [201607010334]
第一作者机构：[1]School of Chinese Materia medica, Guangzhou University of Chinese Medicine, Guangzhou, China[3]Second affiliation hospital, Guangzhou University of Chinese Medicine, Guangzhou, China
共同第一作者：
通讯作者：
通讯机构：[1]School of Chinese Materia medica, Guangzhou University of Chinese Medicine, Guangzhou, China[*1]School of Chinese Materia Medica, Guangzhou University of Chinese Medicine No. 232, Waihuan East Road, Higher Education Mega Center, Guangzhou, Guangdong Province, 510006, China
推荐引用方式(GB/T 7714)：
Tan Qinglong,Qiu Maosong,Cao Di,et al.Triterpenoids with Antiplatelet Aggregation Activity from the Roots of Ilex pubescens[J].PLANTA MEDICA.2017,83(9):797-804.doi:10.1055/s-0042-123708.
APA：
Tan, Qinglong,Qiu, Maosong,Cao, Di,Xiong, Tianqin,Zhang, Lei...&Zhao, Zhongxiang.(2017).Triterpenoids with Antiplatelet Aggregation Activity from the Roots of Ilex pubescens.PLANTA MEDICA,83,(9)
MLA：
Tan, Qinglong,et al."Triterpenoids with Antiplatelet Aggregation Activity from the Roots of Ilex pubescens".PLANTA MEDICA 83..9(2017):797-804
