机构：[1]Department of Neurology, First Affiliated Hospital of Anhui Medical University, Hefei 230022, China[2]National Clinical Research Study Center forKidney Disease, State Key Laboratory for Organ Failure Research, Renal Division, Nanfang Hospital, Southern Medical University, Guangzhou, China[3]School of Health Administration, Anhui University, Hefei, China[4]Department of Neurology, First People’s Hospital, Lianyungang, China[5]Cardiology Department, Peking University First Hospital, Beijing, China[6]Department of Neurology, Guangdong Provincial Hospital of ChineseMedicine, Guangzhou, China[7]Department of Neurology, Xijing Hospital, Forth Military Medical University, Xi’an, China[8]Department of Neurology,Huashan Hospital, Fudan University, Shanghai, China
Our aim was to investigate the association between serum uric acid (SUA) levels and the risk of first stroke in a Chinese population of hypertensive patients. This prospective study enrolled 20,577 hypertensive participants who without a history of stroke, and was conducted from May 2008 to August 2013 in Anqing and Lianyungang (China). A total of 632 (3.1%) first stroke events (510 ischemic events, 120 hemorrhagic events and 2 unspecified stroke events) were identified during a mean 4.5-year follow-up period. The risk of first stroke was not significantly associated with the increased SUA levels; this conclusion was also found after adjustment for gender and age. However, a statistically significant decreased risk of hemorrhagic stroke for the second SUA quartile (Q2) compared to the first quartile (Q1) (HR 0.56, 95%CI: 0.32-0.97, P = 0.037) was found. In addition, when grouped by tertiles of diastolic blood pressure (DBP), the results showed that high SUA lowered the risk of total stroke in participants in the third SUA quartile (Q3) (HR 0.69, 95%CI: 0.49-0.96, P = 0.028) and fourth SUA quartile (Q4) (HR 0.70, 95%CI: 0.50-0.99, P = 0.043) as compared with that in the first quartile (Q1). To sum up, no significant evidence in present study indicates that increased SUA levels are predictive of first stroke in a Chinese population of hypertensive patients.
基金：
Shenzhen AUSA Pharmed Co Ltd; National Science and Technology Major Projects Specialized for "Major New Drugs Innovation and Development" during the 12th Five-Year Plan Period: China Stroke Primary Prevention Trial [zx09101105]; Major State Basic Research Development Program of China (973 program)National Basic Research Program of China [2012 CB517703]; Clinical Center [zx09401013]; Projects of National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81473052, 81441091, 81402735]; Department of Development and Reform, Shenzhen Municipal Government [SFG 20201744]
第一作者机构：[1]Department of Neurology, First Affiliated Hospital of Anhui Medical University, Hefei 230022, China
通讯作者：
通讯机构：[1]Department of Neurology, First Affiliated Hospital of Anhui Medical University, Hefei 230022, China[*1]Department of Neurology, First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Hefei 230022, China
推荐引用方式(GB/T 7714)：
Shi Xiuli,Yang Juan,Wang Liwei,et al.Prospective study of serum uric acid levels and stroke in a Chinese hypertensive cohort[J].CLINICAL AND EXPERIMENTAL HYPERTENSION.2017,39(6):527-531.doi:10.1080/10641963.2017.1281938.
APA：
Shi, Xiuli,Yang, Juan,Wang, Liwei,Zhao, Min,Zhang, Chunyan...&Wang, Kai.(2017).Prospective study of serum uric acid levels and stroke in a Chinese hypertensive cohort.CLINICAL AND EXPERIMENTAL HYPERTENSION,39,(6)
MLA：
Shi, Xiuli,et al."Prospective study of serum uric acid levels and stroke in a Chinese hypertensive cohort".CLINICAL AND EXPERIMENTAL HYPERTENSION 39..6(2017):527-531
