个人中心| | 帮助
高级检索
当前位置： 首页 > 详情页

Association between HLA-DQB1 alleles and susceptibility to coronary artery disease in Southern Han Chinese

| 导出 | |

文献详情

资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Xiong, Yujuan[2] * ; Wang, Lin[1,3] * ; Mo, Pei[1,3] * ; Huang, Guoying[1,3] ; Li, Aiqun[1,3] ; Chai, Renjie[1,3] ; Lin, Xiaozhen[1,3] ; Zhong, Yun[1,3] ; Liu, Bin[1,3] ; Ou, Wenchao[1,3] ; Liu, Benrong[1,3,*1] ; Liu, Shi-ming[1,3,*1] ;
机构： [1]Department of Cardiology, The Second Affiliated Hospital of Guangzhou Medical University, No. 250 Changgang Dong Road, Guangzhou 510260, PR China [2]Department of Laboratory Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, PR China [3]Guangzhou Institute of Cardiovascular Disease, No. 250 Changgang Dong Road, Guangzhou 510260, PR China
出处：
DOI： 10.1016/j.humimm.2017.06.003
ISSN：

关键词： Coronary artery disease (CAD) Human leukocyte antigen (HLA) DQB1 Polymorphisms

摘要：
Accumulated evidence indicates that polymorphisms in human leukocyte antigens (HLA) are associated with susceptibility to coronary artery disease (CAD). However, whether HLA-DQB1 alleles are correlated with susceptibility to CAD is unclear. In this study, significantly lower frequencies of the allele groups (DQB1*03:01:01G and DQB1*05:03:01G) and the genotypes (DQB1*03:01:01G/DQB1*03:01:01G and DQ B1*03:01:01G/DQB1*05:03:01G) were observed in the CAD group compared with that in the controls. However, notably higher frequencies of DQB1*04:01:01G and genotype DQB1*05:01:01G/ DQB1*03:01:01G were observed in the CAD patients than in the controls. Further analysis in subgroups showed that DQB1*03:01:01G was present at a significantly lower frequency in both female and male CAD patients compared with the corresponding controls; however, DQB1*04:01:01G was overtly high only in male CAD patients. CAD patients with diabetes showed a negative association with DQB1*03:01:01G and DQB1*05:03:01G and a positive association with DQB1*04:01:01G, DQB1*03:02:01G and DQB1*03:03:02G. Results of logistic regression analysis indicated that DQB1*03:01:01G and DQB1*05:03:01G were significantly associated with reduced susceptibility to CAD, but DQB1*04:01:01G, DQB1*03:02:01G and DQB1*03 :03:02G had no correlation with CAD. Together, these findings indicate that CAD in Southern Han Chinese is negatively associated with HLA-DQB1*03:01:01G and DQB1*05:03:01G, and males with HLA-DQB1*04:01:01G are likely to have high risk for CAD. (C) 2017 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

基金：
Guangdong Provincial Science and Technology plan project [2014A020212641, 2016A020215142, 2013B021800179]; innovation project from the Department of Education of Guangdong Province [2014KTSCX098]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2016]版：
大类 | 3 区 医学
小类 | 4 区 免疫学
最新[2025]版：
大类 | 4 区 医学
小类 | 4 区 免疫学
JCR分区：
出版当年[2015]版：
Q3 IMMUNOLOGY
最新[2023]版：
Q3 IMMUNOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2015版] 出版当年五年平均 出版前一年[2014版] 出版后一年[2016版]

第一作者：
第一作者机构： [2]Department of Laboratory Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, PR China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Cardiology, The Second Affiliated Hospital of Guangzhou Medical University, No. 250 Changgang Dong Road, Guangzhou 510260, PR China [3]Guangzhou Institute of Cardiovascular Disease, No. 250 Changgang Dong Road, Guangzhou 510260, PR China [*1]Department of Cardiology, The Second Affiliated Hospital of Guangzhou Medical University, No. 250 Changgang Dong Road, Guangzhou 510260, PR China
推荐引用方式(GB/T 7714)：
Xiong Yujuan,Wang Lin,Mo Pei,et al.Association between HLA-DQB1 alleles and susceptibility to coronary artery disease in Southern Han Chinese[J].HUMAN IMMUNOLOGY.2017,78(9):540-546.doi:10.1016/j.humimm.2017.06.003.
APA：
Xiong, Yujuan,Wang, Lin,Mo, Pei,Huang, Guoying,Li, Aiqun...&Liu, Shi-ming.(2017).Association between HLA-DQB1 alleles and susceptibility to coronary artery disease in Southern Han Chinese.HUMAN IMMUNOLOGY,78,(9)
MLA：
Xiong, Yujuan,et al."Association between HLA-DQB1 alleles and susceptibility to coronary artery disease in Southern Han Chinese".HUMAN IMMUNOLOGY 78..9(2017):540-546

相关文献

[1]ΔHLA-DR less than 400 mAb/cellwould be better than the threshold value of 1000 mAb/cell in predicting mortality in pediatric septic patients [2]CALM1 rs3179089 polymorphism might contribute to coronary artery disease susceptibility in Chinese male: a case-control study [3]The roles of ANRIL polymorphisms in coronary artery disease: a meta-analysis [4]Causal association between lipoproteins and risk of coronary artery disease-a systematic review and meta-analysis of Mendelian randomization studies [5]MTHFR C667T等位点基因多态性与CHD发病的关系 [6]HLA-DQB1等位基因与广东汉族人群系统性红斑狼疮相关性研究 [7]Peroxisome proliferators-activated receptor gamma polymorphisms and colorectal cancer risk [8]中国南方汉族和西藏藏族RHCE基因109bp插入序列和733C>G多态性研究 [9]一种鉴定HLA-DQB1第2外显子单倍型的方法 [10]Identification of the novel HLA-DQB1*03:13 allele by next-generation sequencing in a Chinese Han individual.

资源点击量：2018 今日访问量：0 总访问量：645 更新日期：2024-07-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 广东省中医院 技术支持：重庆聚合科技有限公司 地址：广州市越秀区大德路111号