机构：[1]The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou 510006, China广东省中医院[2]College of Chinese Medicines, Guangzhou University of Chinese Medicine, Guangzhou 510006, China[3]Shanghai Research Center for Modernization of Traditional Chinese Medicine, National Engineering Laboratory for TCM Standardization Technology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, China
Biocatalysis of patchoulol (PA) was performed by the fungus Cunninghamella echinulata var. elegans. Eight metabolites (1-8) including four new compounds were obtained, and their structures were elucidated as (5R,8S)-5,8 dihydroxypatchoulol (1), (5R*,9R*)-5,9 dihydroxypatchoulol (2), (6S*, 9S*) -6,9 dihydroxypatchoulol (3), and (4R*) -4 hydroxypatchoulol (4) by spectroscopic analysis. The absolute configuration of 1 was determined by single crystal X-ray diffraction. (C) 2016 Elsevier B.V. All rights reserved.
基金：
National Natural Science Foundation of China [81202398]; Specific Research Construction Project of National Clinical Research Base of TCM [JDZX2012010]
第一作者机构：[1]The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou 510006, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Xu Fangfang,Liao Kangsheng,Liu Yuhong,et al.Biotransformation of patchoulol by Cunninghamella echinulata var. elegans[J].FITOTERAPIA.2016,109:201-205.doi:10.1016/j.fitote.2016.01.001.
APA：
Xu, Fangfang,Liao, Kangsheng,Liu, Yuhong,Zhang, Zhenbiao,Guo, Dean...&Liu, Bo.(2016).Biotransformation of patchoulol by Cunninghamella echinulata var. elegans.FITOTERAPIA,109,
MLA：
Xu, Fangfang,et al."Biotransformation of patchoulol by Cunninghamella echinulata var. elegans".FITOTERAPIA 109.(2016):201-205
