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Elevated serum IL-35 and increased expression of IL-35-p35 or-EBI3 in CD4+CD25+ T cells in patients with active tuberculosis

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收录情况： ◇ SCIE

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机构： [1]Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, No. 1 Xincheng Road, Dongguan523808, China [2]Dongguan 6th People’s Hospital, Dongguan 523008, China [3]Department of Clinical Immunology,Institute of Laboratory Medicine, Guangdong Medical College, No. 1 Xincheng Road, Dongguan 523808, China [4]Department of Clinical Laboratory, Affiliated Hospital of Guangdong Medical college, Zhanjiang 524001, China [5]Department of Laboratory Medicine, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou510120, China [6]Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland21201, United States of America [7]Department of Microbiology and Immunology, Center for Primate BiomedicalResearch, University of Illinois College of Medicine, Chicago 60612, Illinois, United States of America

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关键词： Human active pulmonary tuberculosis interleukin-35 p35 EBI3 CD4(+)CD25(+) T cells

摘要：

Despite the recent appreciation of interleukin 35 (IL-35) function in inflammatory diseases, little is known for IL-35 response in patients with active tuberculosis (ATB). In the current study, we demonstrated that ATB patients exhibited increases in serum IL-35 and in mRNA expression of both subunits of IL-35 (p35 and EBI3) in white blood cells and peripheral blood mononuclear cells. Consistently, anti-TB drug treatment led to reduction in serum IL-35 level and p35 or EBI3 expression. TB infection was associated with expression of p35 or EBI3 protein in CD4(+) but not CD8(+) T cells. Most p35(+)CD4(+) T cells and EBI3(+)CD4(+) T cells expressed Treg-associated marker CD25. Our findings may be important in understanding immune pathogenesis of TB. IL-35 in the blood may potentially serve as a biomarker for immune status and prognosis in TB.

基金：

基金编号： 81570009 81273237 30972779 81101553 2015A030313513 2012KJCX0059 201450715200503 2013C03012 STIF201110 B2012078

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出版当年[2015]版：

大类 | 3 区医学

小类 | 3 区医学：研究与实验 3 区肿瘤学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区医学：研究与实验 4 区肿瘤学

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出版当年[2014]版：

Q2 ONCOLOGY Q2 MEDICINE, RESEARCH & EXPERIMENTAL

最新[2023]版：

Q3 MEDICINE, RESEARCH & EXPERIMENTAL Q4 ONCOLOGY

影响因子： 1.7 最新[2023版] 2.3 最新五年平均 3.402 出版当年[2014版] 3.519 出版当年五年平均 3.226 出版前一年[2013版] 3.146 出版后一年[2015版]

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第一作者机构： [1]Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, No. 1 Xincheng Road, Dongguan523808, China

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通讯作者：

通讯机构： [1]Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, No. 1 Xincheng Road, Dongguan523808, China [3]Department of Clinical Immunology,Institute of Laboratory Medicine, Guangdong Medical College, No. 1 Xincheng Road, Dongguan 523808, China [*1]Department of Clinical Immunology, Institute of Laboratory Medicine, Guangdong Medical University, No.1 Xincheng Road Songshan Lake, Dongguan 523808, P. R. China.

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