机构：[1]Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China广东省中医院[2]The Postdoctoral Research Station, Guangzhou University of Chinese Medicine, Guangzhou, China[3]School of Chinese Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou, China
One new coumarin, 3,5-dihydroxy-7-O--L-rhamno pyranosyl-2H-chromen-2-one (1), was isolated from the whole plant of Sarcandra glabra. The structure was elucidated by spectroscopic methods. Our results indicated that 1 significantly inhibit nitric oxide (NO) production in LPS-induced RAW264.7 macrophages. RT-PCR analysis indicated it inhibited iNOS mRNA expression. In addition, Western blot analysis showed that 1 attenuated LPS-induced synthesis of iNOS protein in the macrophages. These results suggest that 1 could be potential anti-inflammatory agent by down-regulating iNOS expression. [GRAPHICS] .
基金：
National Nature Science Foundation of ChinaNational Natural Science Foundation of China [81202888]
第一作者机构：[1]Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Wang Maojie,Zhao Jin,Zhao Ya,et al.A new coumarin isolated from Sarcandra glabra as potential anti-inflammatory agent[J].NATURAL PRODUCT RESEARCH.2016,30(16):1796-1801.doi:10.1080/14786419.2015.1079186.
APA：
Wang, Maojie,Zhao, Jin,Zhao, Ya,Huang, Run-Yue,Li, Geng...&Li, Xiong.(2016).A new coumarin isolated from Sarcandra glabra as potential anti-inflammatory agent.NATURAL PRODUCT RESEARCH,30,(16)
MLA：
Wang, Maojie,et al."A new coumarin isolated from Sarcandra glabra as potential anti-inflammatory agent".NATURAL PRODUCT RESEARCH 30..16(2016):1796-1801
