机构：[1]Guangzhou Univ Chinese Med, Guangzhou, Peoples R China[2]Guangzhou Univ Chinese Med, Affiliated Hosp 2, Guangzhou, Peoples R China广东省中医院[3]Henan Univ Tradit Chinese Med, Affiliated Hosp 1, Zhengzhou, Peoples R China
Acupuncture is a good treatment for depression in Parkinson's disease (DPD), so the possible mechanism of acupuncture in the treatment of DPD was explored in this study. Firstly, observing the behavioral changes of the DPD rat model, the regulation of monoamine neurotransmitters dopamine (DA) and 5-hydroxytryptamine (5-HT) in the midbrain, the change of alpha-synuclein (alpha-syn) in the striatum, the efficacy of acupuncture in the treatment of DPD was discussed. Secondly, autophagy inhibitors and activators were selected to judge the effect of acupuncture on autophagy in the DPD rat model. Finally, an mTOR inhibitor was used to observe the effect of acupuncture on the mTOR pathway in the DPD rat model. The results showed that acupuncture could improve the motor and depressive symptoms of DPD model rats, increase the content of DA and 5-HT, and decrease the content of alpha-syn in the striatum. Acupuncture inhibited the expression of autophagy in the striatum of DPD model rats. At the same time, acupuncture upregulates p-mTOR expression, inhibits autophagy, and promotes synaptic protein expression. Therefore, we concluded that acupuncture might improve the behavior of DPD model rats by activating the mTOR pathway, inhibiting autophagy from removing alpha-syn and repairing synapses.
基金：
National Natural Science Funds [81804166, 82074522, 81774411]; Guangzhou Science and Technology Planning Project [202102010247]; Natural Science Foundation of Guangdong Province [2018A030310531, 2019A1515012043]; Research Fund for Bajian Talents of Guangdong Provincial Hospital of Chinese Medicine [BJ2022KY10]; Scientific Research Project of Administration of Traditional Chinese Medicine of Guangdong Province [20191129, 20211146]; Key-Area Research and Development Program of Guangdong Province [2020B1111100007]; Double first class and high-level university discipline collaborative innovation team project of Guangzhou University of traditional Chinese medicine [2021xk22]; Special project of high-quality development, inheritance, innovation and improvement of traditional Chinese medicine in Guangdong Province [102]
第一作者机构：[1]Guangzhou Univ Chinese Med, Guangzhou, Peoples R China[2]Guangzhou Univ Chinese Med, Affiliated Hosp 2, Guangzhou, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Guangzhou Univ Chinese Med, Guangzhou, Peoples R China[2]Guangzhou Univ Chinese Med, Affiliated Hosp 2, Guangzhou, Peoples R China[*1]Guangzhou University of Chinese Medicine, Guangzhou, China.
推荐引用方式(GB/T 7714)：
Ning Baile,Wang Zhifang,Wu Qian,et al.Acupuncture inhibits autophagy and repairs synapses by activating the mTOR pathway in Parkinson?s disease depression model rats[J].BRAIN RESEARCH.2023,1808:doi:10.1016/j.brainres.2023.148320.
APA：
Ning, Baile,Wang, Zhifang,Wu, Qian,Deng, Qiyue,Yang, Qing...&Fu, Wenbin.(2023).Acupuncture inhibits autophagy and repairs synapses by activating the mTOR pathway in Parkinson?s disease depression model rats.BRAIN RESEARCH,1808,
MLA：
Ning, Baile,et al."Acupuncture inhibits autophagy and repairs synapses by activating the mTOR pathway in Parkinson?s disease depression model rats".BRAIN RESEARCH 1808.(2023)
