详情页 - 广东省中医院知识库

当前位置：首页 > 详情页

Cellular immune response of dengue virus infection at different phases

文献详情

资源类型：

WOS体系：

收录情况： ◇ SCIE

作者：

机构： [1]Clinical Laboratory, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China [2]Clinical Laboratory, Traditional Chinese Medicine Hospital of Guangdong Province, Guangzhou 510120, China [3]Department of Pathogenic Biology and Immunology, Institute of Immunology, Guangzhou Medical University, Guangzhou 511436, China [4]Functional Experiment Centre, Guangzhou Medical University, Guangzhou 511436, China [5]ICU, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 440100, China

出处：

ISSN：

关键词： Dengue fever peripheral blood T cells Th17 cells

摘要：

Dengue fever is one of the major human infectious diseases in tropical and subtropical areas every year. In the present article, blood samples were collected from patients in hospital of Guangzhou city. Dengue patients were determined at the IgM(-)IgG(-), IgM(+), IgM(+)IgG(+) and IgG(+) phases according to the secretion of IgM and IgG antibodies. The cellular characteristics of patients at these four phases were compared. Results showed that the counts of leukocyte and platelet at all four phases of illness were significantly lower than that in health control, with IgM(+) phase showing the lowest counts among four phases. Moreover, white blood cell profile at each phase had different degrees of change. The percentage of CD3(+) cells decreased significantly at four phases in comparison with healthy controls, and IgG(+) phase exhibited the lowest among them. These patients at IgG(+) phase exhibited enhanced production of Th1 cells compared with the other patients (P<0.01). The numbers of Th17 and Tregs cells were elevated at different phase in patients. Th17 cell appears to be associated with dengue fever.

基金：

语种：

被引次数：

WOS：

中科院(CAS)分区：

出版当年[2015]版：

大类 | 4 区医学

小类 | 4 区医学：研究与实验

最新[2025]版：

大类 | 4 区医学

小类 | 4 区医学：研究与实验

JCR分区：

出版当年[2014]版：

Q4 MEDICINE, RESEARCH & EXPERIMENTAL

最新[2023]版：

Q4 MEDICINE, RESEARCH & EXPERIMENTAL

影响因子： 0.2 最新[2023版] 0.2 最新五年平均 1.277 出版当年[2014版] 1.412 出版当年五年平均 1.422 出版前一年[2013版] 1.075 出版后一年[2015版]

第一作者：

第一作者机构： [1]Clinical Laboratory, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China

共同第一作者：

通讯作者：

通讯机构： [1]Clinical Laboratory, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China [3]Department of Pathogenic Biology and Immunology, Institute of Immunology, Guangzhou Medical University, Guangzhou 511436, China [*1]Clinical Labo- ratory, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China. [*2]Department of Pathogenic Biology and Immunology, Institute of Immunology, Guang- zhou Medical University, Guangzhou 511436, China

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]Cellular immune response of dengue virus infection at different phases [2]Baicalin attenuates TNBS-induced colitis in rats by modulating the Th17/Treg paradigm. [3]Chronic stress-induced depression requires the recruitment of peripheral Th17 cells into the brain [4]The association of Th17/Treg cells expression in peripheral blood and chronic spontaneous urticaria: A protocol of systematic review and meta-analysis. [5]177例登革热患者临床检验结果分析 [6]登革热实验室检测的结果分析 [7]狼疮性肾炎患者Th1、Th17及Th22细胞亚群的变化及临床意义 [8]Peripheral blood lymphocyte subsets predict the efficacy of TACE with or without PD-1 inhibitors in patients with hepatocellular carcinoma: a prospective clinical study [9]Serum Cytokine Profiles in Patients with Dengue Fever at the Acute Infection Phase. [10]Indoleamine 2,3-dioxygenase 1 deficiency attenuates CCl4-induced fibrosis through Th17 cells down-regulation and tryptophan 2,3-dioxygenase compensation.