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Cellular immune response of dengue virus infection at different phases

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机构： [1]Clinical Laboratory, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China [2]Clinical Laboratory, Traditional Chinese Medicine Hospital of Guangdong Province, Guangzhou 510120, China [3]Department of Pathogenic Biology and Immunology, Institute of Immunology, Guangzhou Medical University, Guangzhou 511436, China [4]Functional Experiment Centre, Guangzhou Medical University, Guangzhou 511436, China [5]ICU, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 440100, China.

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关键词： Dengue fever Peripheral blood T cells Th17 cells

摘要：

Dengue fever is one of the major human infectious diseases in tropical and subtropical areas every year. In the present article, blood samples were collected from patients in hospital of Guangzhou city. Dengue patients were determined at the IgM-IgG-, IgM+, IgM+IgG+ and IgG+ phases according to the secretion of IgM and IgG antibodies. The cellular characteristics of patients at these four phases were compared. Results showed that the counts of leukocyte and platelet at all four phases of illness were significantly lower than that in health control, with IgM+ phase showing the lowest counts among four phases. Moreover, white blood cell profile at each phase had different degrees of change. The percentage of CD3+ cells decreased significantly at four phases in comparison with healthy controls, and IgG+ phase exhibited the lowest among them. These patients at IgG+ phase exhibited enhanced production of Th1 cells compared with the other patients (P<0.01). The numbers of Th17 and Tregs cells were elevated at different phase in patients. Th17 cell appears to be associated with dengue fever. © 2016, E-Century Publishing Corporation. All rights reserved.

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出版当年[2015]版：

大类 | 4 区医学

小类 | 4 区医学：研究与实验

最新[2025]版：

大类 | 4 区医学

小类 | 4 区医学：研究与实验

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第一作者机构： [1]Clinical Laboratory, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China

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通讯机构： [1]Clinical Laboratory, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China [3]Department of Pathogenic Biology and Immunology, Institute of Immunology, Guangzhou Medical University, Guangzhou 511436, China [*1]Clinical Labo-ratory, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China. [*2]Department of Pathogenic Biology and Immunology, Institute of Immunology, Guang-zhou Medical University, Guangzhou 511436, China.

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