The aim of the present study was to develop extended release biodegradable polymeric implants of ketorolac tromethamine using biodegradable polymer Polycaprolactone (PCL) and Polylactide-coglycolide (PLGA) and chitosan for effective management of pain and inflammation in vertebral fracture. The prepared implants were evaluated for length, diameter, uniformity of weight, drug content, hardness, swelling index, in vitro drug release, in vivo analgesic and antiinflammatory activity in rats and in vivo bioavailability and analgesic activity in humans. The physicochemical properties of implants were found to be satisfactory. The implants of ketorolac showed good swelling (swelling increased with PCL concentration), drug content (87.1 to 96.5%) and the in vitro dissolution (29-48% after 48 h). The implants prepared from the PCL and PLGA in 1:1 ratio (IK3) was found to be very potential in the patients of vertebral fracture. The implant formulation IK3 showed good physicochemical properties including the highest drug content, the best swelling, good drug release and the best in vivo analgesic and anti-inflammatory performance.