机构：[1]Department of Chinese Medicine, Guangdong Women and Children Hospital, Guangzhou, China, 510010[2]The Second School of Clinic Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China,510405广东省中医院深圳市中医院深圳医学信息中心[3]The Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China, 510120广东省中医院
Objective: To analyze the component law of Chinese medicines for gout, and develop new prescriptions for gout through unsupervised data mining methods. Methods: Chinese medicine recipes for gout were collected and recorded in the database, and then the correlation coefficient between herbs, core combinations of herbs and new prescriptions were analyzed by using modified mutual information, complex system entropy cluster and unsupervised hierarchical clustering, respectively. Results: Based on the analysis of 70 Chinese medicine recipes for gout, 22 drugs with high-frequency occurrence in these recipes, 26 frequently-used herb pairs and 5 core combinations were founded, and 3 new recipes for gout were developed. Conclusion: Chinese medicines for gout were mainly consist of blood-activating and stasis-dispelling medicinal, dampness-resolving medicinal, spleen fortifying and dampness draining medicinal, wind-dampnessdispelling and heatclearing medicinal. The the treatment principle for gout is to eliminate the pathogenic factors. Radix Clematidis, Rhizoma Atractylodis, Rhizoma Dioscoreae Septemlobae, Semen Coicis, Cortex Phellodendri, Rhizoma Alismatis, Rhizoma Anemarrhenae, Radix Achyranthis Bidentatae, Radix Glycyrrhizae, Poria, Semen Plantaginis, and Rhizoma Atractylodis Macrocephalae are the main herbal drugs used in the treatment of gout.
基金：
Science and Technology Planning
Project of Guangdong Province, China, (Grant No.
2006B35602012, 2011B031300014, 2011B031700027,
2012B061700036, 2012B061700037), and Medical
Scientific Research Foundation of Guangdong Province,
China (Grant No. A2005269), and Administration of
Traditional Chinese Medicine of Guangdong Province, China (Grant No. 101061, 20121004ˈ 20123006), and the
Specialized Research Fund for the Doctoral Program of
Higher Education of China (Grant No. 20124425110004)
第一作者机构：[1]Department of Chinese Medicine, Guangdong Women and Children Hospital, Guangzhou, China, 510010
通讯作者：
推荐引用方式(GB/T 7714)：
Pan Bi-qi,Yang Ji-yuan,Li Hong-mei,et al.Research on the Component Law of Chinese Medicine for Gout and the Development of New Recipes through Unsupervised Data Mining Methods[J].2013 IEEE INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICINE (BIBM).2013,doi:10.1109/BIBM.2013.6732673.
APA：
Pan, Bi-qi,Yang, Ji-yuan,Li, Hong-mei,Pan, Jian-ke,Lu, Jia-jing&Liu, Jun.(2013).Research on the Component Law of Chinese Medicine for Gout and the Development of New Recipes through Unsupervised Data Mining Methods.2013 IEEE INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICINE (BIBM),,
MLA：
Pan, Bi-qi,et al."Research on the Component Law of Chinese Medicine for Gout and the Development of New Recipes through Unsupervised Data Mining Methods".2013 IEEE INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICINE (BIBM) .(2013)
