机构：[1]Guangdong Prov Hosp Integrated Tradit Chinese & W, Foshan 528200, Peoples R China[2]Guangzhou Univ Chinese Med, Sch Clin Med 2, Guangzhou 510120, Peoples R China广东省中医院
To analyze the component law of Chinese medicines for rheumatoid arthritis, and develop new prescriptions for rheumatoid arthritis through mutual Information mining methods. Chinese medicine recipes for rheumatoid arthritis were collected and recorded in the database, and then the correlation coefficient between herbs, core combinations of herbs and new prescriptions were analyzed by using modified mutual information, complex system entropy cluster and unsupervised hierarchical clustering, respectively. Based on the analysis of 63 Chinese medicine recipes for rheumatoid arthritis, 30 drugs with high-frequency and the distribution of Four Qi and Five Flavors of Chinese medicines occurrence in these recipes, 34 frequently-used herb pairs and 9 core combinations were founded, and 3 new recipes for rheumatoid arthritis were developed. Chinese medicines for rheumatoid arthritis were mainly consist of blood-activating and stasis-dispelling edicinal, wind-dampnessdispelling and heatclearing medicinal, heatclearing and detoxicating medicinal, tonifying and replenishing medicinal. So, the therapeutic principle for rheumatoid arthritisis to reinforce the healthy qi and eliminate the pathogenic factors. Radix Gentianae Macrophyllae, Rhizoma Chuanxiong,Radix Glycyrrhizae,Radix Angelicae Pubescentis,Radix Paeoniae Alba,Radix Angelicae Sinensis,Radix Achyranthis Bidentatae,Ramulus Cinnamomi,Rhizoma Et Radix Notopterygii and Radix Astragali are the main herbal drugs used in the treatment of rheumatoid arthritis.
基金：
Science and Technology
Planning Project of Guangdong Province, China, (Gran No.2012B061700036, No.2012B061700037), and
Administration of Traditional Chinese Medicine of
Guangdong Province, China (Grant No. 20123006),and
the Specialized Research Fund for the Doctoral
Program of Higher Education of China (Grant No.
20124425110004),and Guangdong Medical
Science and Technology Research Fund(Grant No.
A2011226)
语种：
外文
WOS：
第一作者：
第一作者机构：[1]Guangdong Prov Hosp Integrated Tradit Chinese & W, Foshan 528200, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Qiu Qingzhong,Guo Da,Pan Jianke,et al.Mutual Information Mining for Component Law and Development of New Recipes for Rheumatoid Arthritis[J].2013 IEEE INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICINE (BIBM).2013,
APA：
Qiu, Qingzhong,Guo, Da,Pan, Jianke,Ma, Zhenwei,Liu, Jun&Cao, Xuewei.(2013).Mutual Information Mining for Component Law and Development of New Recipes for Rheumatoid Arthritis.2013 IEEE INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICINE (BIBM),,
MLA：
Qiu, Qingzhong,et al."Mutual Information Mining for Component Law and Development of New Recipes for Rheumatoid Arthritis".2013 IEEE INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICINE (BIBM) .(2013)
