The intervention of traditional Chinese medicine always focus on two highlight aspects: one is the ZHENG (syndrome) differentiation and treatment, the other is the concept of holism. By the process of fully collecting clinical data, establishing data warehouse and model, making the best of mathematical statistics, data mining, etc., the Chinese medicine (CM) clinical auxiliary decision towards the patients can be better maintained, promoted and accomplished, which can help the construction of clinical decision support system (CDSS), the improvement of clinical efficacy and the inheritance of CM knowledge. In this paper, the author went over the traits of CM clinical experiences based on the clinical decision support thoughts, and then attempted to summarize an architecture approach to syndrome differentiation of information technology, so as to serve as reference for the practice of CM standardization.