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Nanomedicines: Redefining traditional medicine.

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机构: [a]Southern Marine Science and Engineering Guangdong Laboratory (Zhanjiang), Zhanjiang 524023, China [b]First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China [c]Guangdong Key Laboratory for Research and Development of Natural Drugs, The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang 524023, China [d]The Key Lab of Zhanjiang for R&D Marine Microbial Resources in the Beibu Gulf Rim, Guangdong Medical University, Zhanjiang 524023, China [e]The Marine Biomedical Research Institute of Guangdong Zhanjiang, Zhanjiang 524023, China
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关键词: Cancer Nanoparticles Nanotechnology Targeting therapy Review

摘要:
Nanomedicines offer nanoscale drug delivery system. They offer ways of promising drug transportation, and address the issues of lack of targeting and permeability of traditional drugs. The physical and chemical properties in the domain of nanomedicine applications in vivo have not been sufficiently delivered. What's more, the metabolic of nanomedicines is not clear enough. Those factors which mentioned above determine that many nanomedicines have not yet realized clinical application due to their safety problems and in vivo efficacy. For example, they may cause immune response and cytotoxicity, as well as the ability to clear organs in vivo, the penetration ability of them and the lack of targeting ability may also cause poor efficacy of drugs in vivo. In this review, the new progresses of different kinds of nanomedicines (including gold nanoparticles, nanorobots, black phosphorus nanoparticles, brain diseases, gene editing and immunotherapy etc.) in anti-tumor, antibacterial, ocular diseases and arteriosclerosis in recent years were summarized. Their shortcomings were pointed out, and the new methods to improve the biosafety and efficacy were summarized. Copyright © 2020 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

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出版当年[2020]版:
大类 | 2 区 医学
小类 | 2 区 药学 3 区 医学:研究与实验
最新[2025]版:
大类 | 2 区 医学
小类 | 2 区 医学:研究与实验 2 区 药学
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第一作者机构: [a]Southern Marine Science and Engineering Guangdong Laboratory (Zhanjiang), Zhanjiang 524023, China
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通讯机构: [a]Southern Marine Science and Engineering Guangdong Laboratory (Zhanjiang), Zhanjiang 524023, China [c]Guangdong Key Laboratory for Research and Development of Natural Drugs, The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang 524023, China [d]The Key Lab of Zhanjiang for R&D Marine Microbial Resources in the Beibu Gulf Rim, Guangdong Medical University, Zhanjiang 524023, China [e]The Marine Biomedical Research Institute of Guangdong Zhanjiang, Zhanjiang 524023, China [*1]Guangdong Key Laboratory for Research and Development of Natural Drugs, The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang 524023, China.
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