机构:[a]2nd Affiliated Clinical Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China[b]Department of Natural Medicinal Chemistry, Shanghai Institute of Materia Medica, CAS, 555 ZuChongzhi Road, Shanghai 201203, PR China[c]Department of Natural Products Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, PR China
Chemical investigation of the aerial part of Chonemorpha griffithii has led to the isolation of 20 compounds, comprising six lignans (1-6), six triterpenoids (7-12), four phenolic acids (13-16), two flavonoids (17 and 18), one cyclitol (19) and one aliphatic acid (20). Among them, 5'-methoxy-7'-oxomatairesinol (1) was identified to be a new lignan. It is the first report of the presence of those compounds in this genus. Two 24-methyl-29-norcycloartane triterpenoids (10 and 11) were considered as the chemotaxonomic markers for the species C griffithii. (C) 2013 Elsevier Ltd. All rights reserved.
基金:
The authors thanks the National Science & Technology Major Project “Key New Drug Creation and Manufacturing Program”,
China (No. 2012ZX09301001-001), and the National Natural Science Foundation of China (Nos. 81072545 and
21202182) for the financial supports.