Quantifying glucose permeability and enhanced light penetration in ex vivo human normal and cancerous esophagus tissues with optical coherence tomography
机构：[1]MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, South China Normal University, Guangzhou 510631,Guangdong Province, China[2]Department of Anesthesiology, the Second Affiliated Clinical Hospital of Guangzhou University of Traditional Chinese Medicine,Guangzhou 510120, Guangdong Province, China[3]Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education of China, Fujian Normal University,Fuzhou 350007, Fujian, China[4]Department of Surgery, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, China中山大学附属第一医院[5]Laser Medicine Lab, Department of Biomedical Engineering, School of Pre-Clinical Medicine of Sun Yet-Sen University, GuangzhouGuangdong 510080, China
We report our pilot results on quantification of glucose (G) diffusion permeability in human normal esophagus and ESCC tissues in vitro by using OCT technique. The permeability coefficient of 40% aqueous solution of G was found to be (1.74 +/- 0.04) x 10(-5) cm/s in normal esophagus and (2.45 +/- 0.06) x 10(-5) cm/s in ESCC tissues. The results from this study indicate that ESCC tissues had a higher permeability coefficient compared to normal esophageal tissues, and the light penetration depths gradually increase with the increase of applied topically with G time for the normal esophageal and ESCC tissues. The results indicate that the permeability coefficient of G in cancer tissues was 1.41-fold than that in normal tissues, and the light penetration depth for the ESCC tissues is significantly smaller than that of normal esophagus tissues in the same time range. These results demonstrate that the optical clearing of normal and cancer esophagus tissues are improved after application of G. [GRAPHICS] OCTSS graphs as a function of time recorded from ESCC tissues during G 40% diffusion experiments (C) 2011 by Astro Ltd. Published exclusively by WILEY-VCH Verlag GmbH & Co. KGaA
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [60778047]; Natural Science Foundation of Guangdong ProvinceNational Natural Science Foundation of Guangdong Province [06025080]; Key Science and Technology Project of Guangdong Province of China [2005B50101015, 2008B090500125]; Key Science and Technology Project of Guangzhou City of China [2008Z1-D391]
第一作者机构：[1]MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, South China Normal University, Guangzhou 510631,Guangdong Province, China
通讯作者：
推荐引用方式(GB/T 7714)：
Q.L. Zhao,J.L. Si,Z.Y. Guo,et al.Quantifying glucose permeability and enhanced light penetration in ex vivo human normal and cancerous esophagus tissues with optical coherence tomography[J].LASER PHYSICS LETTERS.2011,8(1):71-77.doi:10.1002/lapl.201010081.
APA：
Q.L. Zhao,J.L. Si,Z.Y. Guo,H.J. Wei,H.Q. Yang...&L.Q. Li.(2011).Quantifying glucose permeability and enhanced light penetration in ex vivo human normal and cancerous esophagus tissues with optical coherence tomography.LASER PHYSICS LETTERS,8,(1)
MLA：
Q.L. Zhao,et al."Quantifying glucose permeability and enhanced light penetration in ex vivo human normal and cancerous esophagus tissues with optical coherence tomography".LASER PHYSICS LETTERS 8..1(2011):71-77
