机构：[1]Department of Clinical Trial Design and Management, Translational Research Center, Graduate School of Medicine, Kyoto University, Kyoto, Japan[2]Translational Research Informatics Center, Kobe, Japan[3]DME Training Center, Institute of Clinical Pharmacology, Guangzhou University of Traditional Chinese Medicine, Guangzhou, China[4]Division of Clinical Epidemiology, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, China广东省中医院[5]Department of Clinical Innovative Medicine, Translational Research Center, Graduate School of Medicine, Kyoto University, Kyoto, Japan[6]International Innovation Center, Kyoto University, Kyoto, Japan[7]Ichikawa Construction, Gifu, Japan[8]Aichi Micro Intelligent, Aichi, Japan[9]Nagoya Industrial Sciences Research Institute, Aichi, Japan
The effects of extremely low-frequency electromagnetic fields (ELF-EMFs) on blood pressure (BP) are controversial. In this double-blind, randomized, sham-controlled study, we examined the effects of repeated exposure to a 1-mu T ELF-EMF on BP in 20 humans with mild-to-moderate hypertension. Subjects were randomly assigned to either the ELF-EMF group or the sham group. Subjects in the ELF-EMF group were exposed to an ELF-EMF (6-and 8 Hz, respectively, peak magnetic field 1 mu T, peak electric field 10 Vm(-1)) for at least two 10- to 15-min sessions per week, over a period of 4 weeks. In the sham group, the EMF-generating apparatus was not active. We obtained systolic and diastolic BP (SBP and DBP, respectively) measurements at registration and before and after each ELF-EMF exposure session. Subjects in the ELF-EMF and sham groups had mean ages of 52.8 and 55.1 years, and were exposed to a mean of 9.9 and 9.0 sessions, respectively. There was a significant difference between the ELF-EMF and sham groups with respect to change in SBP value between baseline and the end of the exposure regimen (P-0.02), but not with respect to change in DBP (P-0.21). There were no adverse events other than mild paresthesia of the hands of two subjects in the ELF-EMF group. Our results suggest that repeated exposure to an ELF-EMF has a BP-lowering effect on humans with mild-to-moderate hypertension. Hypertension Research (2011) 34, 372-377; doi:10.1038/hr.2010.246; published online 20 January 2011
第一作者机构：[1]Department of Clinical Trial Design and Management, Translational Research Center, Graduate School of Medicine, Kyoto University, Kyoto, Japan[2]Translational Research Informatics Center, Kobe, Japan[*1]Department of Clinical Trial Design and Management, Translational Research Center, Graduate School of Medicine, Kyoto University, Shogoin Kawahara-cho 54, Sakyo-ku, Kyoto 606-8507, Japan
共同第一作者：
通讯作者：
通讯机构：[1]Department of Clinical Trial Design and Management, Translational Research Center, Graduate School of Medicine, Kyoto University, Kyoto, Japan[2]Translational Research Informatics Center, Kobe, Japan[*1]Department of Clinical Trial Design and Management, Translational Research Center, Graduate School of Medicine, Kyoto University, Shogoin Kawahara-cho 54, Sakyo-ku, Kyoto 606-8507, Japan
推荐引用方式(GB/T 7714)：
Nishimura Tsutomu,Tada Harue,Guo Xinfeng,et al.A 1-μT extremely low-frequency electromagnetic field vs sham control for mild-to-moderate hypertension: a double-blind, randomized study[J].HYPERTENSION RESEARCH.2011,34(3):372-377.doi:10.1038/hr.2010.246.
APA：
Nishimura, Tsutomu,Tada, Harue,Guo, Xinfeng,Murayama, Toshinori,Teramukai, Satoshi...&Fukushima, Masanori.(2011).A 1-μT extremely low-frequency electromagnetic field vs sham control for mild-to-moderate hypertension: a double-blind, randomized study.HYPERTENSION RESEARCH,34,(3)
MLA：
Nishimura, Tsutomu,et al."A 1-μT extremely low-frequency electromagnetic field vs sham control for mild-to-moderate hypertension: a double-blind, randomized study".HYPERTENSION RESEARCH 34..3(2011):372-377
