机构：[1]Department of Clinical Pharmacology, Guangdong Provincial Hospital of TCM Affiliated to Guangzhou University of TCM, Guangzhou, China大德路总院药学部广东省中医院[2]College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
Rapid-resolution liquid chromatography coupled with electrospray ion trap multistage mass spectrometry (ESI-MS (n) ) and electrospray quadrupole-time-of-flight mass spectrometry (ESI-Q-TOF) has been utilized to separate and characterize the phenolic components in Erigeron injections. After extensive separation on the column, each peaks' potential structures were obtained based on their accurate mass supplied by ESI-Q-TOF and chemical database retrieval, and confirmed by ESI-MS (n) . A total of 44 compounds were identified or tentatively characterized and fifteen of them reported for the first time. In addition, the developed method was applied to monitor the elimination of phenolic compounds in rats after intravenous administration of 4 mL kg(-1) Erigeron injection. The caffeoylquinic acids and flavonoids of the Erigeron injection were quickly degraded and most of them reached the low limit of detection (SNR < 3) at 2 h post-injection.
基金：
National Science and Technology Major Project of China [2009ZX09304-002]
语种：
外文
被引次数：
WOS：
中科院(CAS)分区：
出版当年[2009]版：
大类|4 区化学
小类|4 区生化研究方法4 区分析化学
最新[2025]版：
大类|4 区化学
小类|4 区生化研究方法4 区分析化学
JCR分区：
出版当年[2008]版：
Q3CHEMISTRY, ANALYTICALQ4BIOCHEMICAL RESEARCH METHODS
最新[2023]版：
Q4BIOCHEMICAL RESEARCH METHODSQ4CHEMISTRY, ANALYTICAL
第一作者机构：[1]Department of Clinical Pharmacology, Guangdong Provincial Hospital of TCM Affiliated to Guangzhou University of TCM, Guangzhou, China[2]College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
通讯作者：
推荐引用方式(GB/T 7714)：
Zhang Yufeng,Zhao Qinqin,Ma Jinfei,et al.Chemical Characterization of Phenolic Compounds in Erigeron Injection by Rapid-Resolution LC Coupled with Multi-Stage and Quadrupole-TOF-MS[J].CHROMATOGRAPHIA.2010,72(7-8):651-658.doi:10.1365/s10337-010-1703-x.
APA：
Zhang, Yufeng,Zhao, Qinqin,Ma, Jinfei,Wu, Bin&Zeng, Xing.(2010).Chemical Characterization of Phenolic Compounds in Erigeron Injection by Rapid-Resolution LC Coupled with Multi-Stage and Quadrupole-TOF-MS.CHROMATOGRAPHIA,72,(7-8)
MLA：
Zhang, Yufeng,et al."Chemical Characterization of Phenolic Compounds in Erigeron Injection by Rapid-Resolution LC Coupled with Multi-Stage and Quadrupole-TOF-MS".CHROMATOGRAPHIA 72..7-8(2010):651-658
