机构：[1]The Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal University, Changsha, Hunan, P.R. China[2]Guangdong Provincial Academy of Chinese Medical Science, Guangdong Provincial Hospital of TCM, Guangzhou, P.R. China广东省中医院[3]College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, Hunan, P.R. China
Though taurine has been reported very useful in preventing oxidative stress and various age-related diseases, the detailed biochemical mechanism of its biological functions is not well understood. Direct reaction of malondialdehyde (MDA) with taurine was studied using spectrofluorometry, spectrophotometry and liquid chromatography online with mass spectrometry (LC/MS). The results indicated that taurine reacted readily with MDA at supraphysiological conditions to yield mainly two products: a fluorescent 1,4-dihydropyridine and non-fluorescent enaminal derivatives. Taurine also significantly inhibited the formation of lipofuscin-like fluorescence induced by MDA-modified bovine serum albumin. These findings suggested that taurine effectively reduces carbonyl stress due to the amino group in its molecular structure, and we propose that it should be the mechanism related with the pathophysiological functions of taurine in the biological system.
基金：
National 863 Grants of China (2008AA02Z411), the National
Natural Science Funds of China (30800207) and the
Hunan Normal University Doctoral Funds (53112-1392)
第一作者机构：[1]The Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal University, Changsha, Hunan, P.R. China[3]College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, Hunan, P.R. China
共同第一作者：
通讯作者：
通讯机构：[1]The Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal University, Changsha, Hunan, P.R. China[2]Guangdong Provincial Academy of Chinese Medical Science, Guangdong Provincial Hospital of TCM, Guangzhou, P.R. China[*1]College of Life Sciences, Hunan Normal University, 175 Lushan Road, Changsha, Hunan 410081, P.R. China
推荐引用方式(GB/T 7714)：
Li Guolin,Tang Ting,Peng Mijun,et al.Direct reaction of taurine with malondialdehyde: evidence for taurine as a scavenger of reactive carbonyl species[J].REDOX REPORT.2010,15(6):268-274.doi:10.1179/135100010X12826446921743.
APA：
Li, Guolin,Tang, Ting,Peng, Mijun,He, Hong&Yin, Dazhong.(2010).Direct reaction of taurine with malondialdehyde: evidence for taurine as a scavenger of reactive carbonyl species.REDOX REPORT,15,(6)
MLA：
Li, Guolin,et al."Direct reaction of taurine with malondialdehyde: evidence for taurine as a scavenger of reactive carbonyl species".REDOX REPORT 15..6(2010):268-274
