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Jinfu’an decoction inhibits invasion and metastasis in human lung cancer cells (H1650) via p120ctn-mediated induction and Kaiso

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机构： [a]The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China [b]Guangdong Second Provincial Traditional Chinese Medicine Hospital, Guangzhou, Guangdong, China [c]Affiliated Hospital of Qinghai University, Affiliated Cancer Hospital of Qinghai University, Xining, Qinghai, China [d]Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China

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关键词： Chinese medicinal formula Invasion and metastasis Jinfu’an decoction Lung cancer p120ctn and Kasio

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Background: Previous research showed that Jin-Fu-An decoction has a significant effect on lung cancer. However, it remains unclear whether p120ctn and its transcription factor Kaiso play a role in lung cancer cell proliferation, adhesion, migration, and metastasis. Material/Methods: Proliferation inhibition was detected by CCK-8 assay. The migration and invasion were detected using Transwell assay. The location and expression of p120ctn and Kaiso were monitored by immunofluorescence staining. The expression changes of p120ctn, its isoform 1A, its S288 phosphorylation, and Kaiso were measured by Western blot assay. Results: The lung cancer cell line H1650 administered Jin-Fu-An decoction had significantly reduced the growth in dose-dependent and time-dependent manners. Migration and metastasis were significantly inhibited by application of Jin-Fu-An decoction in a dose-dependent manner. Additionally, Jin-Fu-An decoction decreased the expressions of p120ctn, its isoform 1A, and its S288 phosphorylation, but the protein level of Kaiso was elevated. Conclusions: Jin-Fu-An decoction inhibits the proliferation, adhesion, migration, and metastasis though down-regulation of p120ctn or its isoform 1A expression, mediating the up-regulation of Kaiso. The underlying mechanism of Jin-Fu-An decoction might involve targeting the lower expression of p120ctn S288 phosphorylation, which suggests that Jin-Fu-An decoction may be a potential therapeutic measure as prevention and control of recurrence and metastasis of lung cancer. © Med Sci Monit.

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出版当年[2017]版：

大类 | 4 区医学

小类 | 4 区医学：研究与实验

最新[2025]版：

大类 | 4 区医学

小类 | 4 区医学：研究与实验

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第一作者机构： [a]The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China

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