机构：[1]Guangdong Provincial Corps Hospital of Chinese People’s Armed Police Forces, Guangzhou Medical University, PR China[2]The Third Affiliated Hospital of GuangZhou University of Chinese Medicine, PR China[3]Air Force General Hospital, PR China
This study was designed to determine whether plasma CXCL12 levels in postmenopausal osteoporosis (PMOP) patients
are related to disease severity. A total of 91 PMOP females were recruited, and 88 postmenopausal non-osteoporotic
(PMNOP) women and 90 healthy females were incorporated as controls. Dual-energy X-ray absorptiometry was utilised
to explore bone-mineral density (BMD). The Genant semi-quantitative grading scale was used for vertebral fractures,
and plasma CXCL12/SDF-1 levels were investigated by ELISA. Plasma TNF-a and C-telopeptide cross-linked collagen
type 1 (CTX-1) were also tested. The Oswestry Disability Index (ODI) and a visual analogue scale (VAS) were
completed in order to assess clinical severity. Plasma CXCL12 levels were considerably elevated in PMOP females
compared to PMNOP women and healthy controls. Plasma CXCL12 concentrations were positively correlated with the
Genant grading system. We observed significant and negative correlations of plasma CXCL12 levels with lumbar spine,
femoral neck and total hip BMD. Moreover, plasma CXCL12 concentrations were positively correlated to VAS and ODI,
as well as plasma TNF-a and CTX-1 levels. In conclusion, elevated plasma CXCL12 levels are correlated with disease
severity in PMOP females
基金：
Project of Administration of traditional Chinese Medicine Guangdong
Provincial of China (No. 20171143).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类|3 区生物
小类|4 区生化与分子生物学4 区免疫学4 区医学：研究与实验4 区微生物学
最新[2025]版：
大类|4 区医学
小类|4 区生化与分子生物学4 区免疫学4 区医学：研究与实验4 区微生物学
第一作者：
第一作者机构：[1]Guangdong Provincial Corps Hospital of Chinese People’s Armed Police Forces, Guangzhou Medical University, PR China[2]The Third Affiliated Hospital of GuangZhou University of Chinese Medicine, PR China
通讯作者：
通讯机构：[1]Guangdong Provincial Corps Hospital of Chinese People’s Armed Police Forces, Guangzhou Medical University, PR China[*1]Yan-Lin Road 268, Tian He District, Guangdong Provincial Corps Hospital of Chinese People’s Armed Police Forces, Guangzhou Medical University, GuangZhou, Guang Dong Province, PR China, 510507.
推荐引用方式(GB/T 7714)：
Yang Xian-Wen,Huang Hong-Xing,Wang Fei,et al.Elevated plasma CXCL12/SDF-1 levels are linked with disease severity of postmenopausal osteoporosis.[J].Innate immunity.2020,26(3):222-230.doi:10.1177/1753425919883365.
APA：
Yang Xian-Wen,Huang Hong-Xing,Wang Fei,Zhou Qi-Lin,Huang Yan-Qiang&Qin Ru-Zi.(2020).Elevated plasma CXCL12/SDF-1 levels are linked with disease severity of postmenopausal osteoporosis..Innate immunity,26,(3)
MLA：
Yang Xian-Wen,et al."Elevated plasma CXCL12/SDF-1 levels are linked with disease severity of postmenopausal osteoporosis.".Innate immunity 26..3(2020):222-230
