机构：[1]Guangdong Provincial Corps Hospital of Chinese People’s Armed Police Forces, Guangzhou Medical University, GuangZhou, GuangDong Province, 510006, PR China[2]Air Force General Hospital, Beijing 100142, PR China[3]The Third Affiliated Hospital of GuangZhou University of Chinese Medicine, GuangZhou, GuangDong Province, 510170, PR China
To investigate if the serum CC motif ligand 4 (CCL4) levels are linked to disease severity in patients with postmenopausal osteoporosis (PMOP).
We enrolled 66 PMOP females, 68 postmenopausal nonosteoporotic women and 67 healthy women of childbearing age. Bone mineral densities were assessed with dual x-ray absorptiometry scans. The Oswestry disability index and the visual analog scale were employed to quantify functional ability and severity of symptoms. Serum CCL4 levels were examined with a quantitative sandwich enzyme-linked immunosorbent assay.
We observed a significant negative correlation of CCL4 serum levels with bone mineral density. Furthermore, serum CCL4 concentrations were significantly related to the visual analog scale and Oswestry Disability Index scores.
Serum CCL4 is a potential biomarker to evaluate disease severity in PMOP females.
基金：
This study is funded by the National Nature Science Foundation of China (no. 81674004).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|4 区医学
小类|4 区医学：研究与实验
最新[2025]版：
大类|4 区医学
小类|4 区医学：研究与实验
第一作者：
第一作者机构：[1]Guangdong Provincial Corps Hospital of Chinese People’s Armed Police Forces, Guangzhou Medical University, GuangZhou, GuangDong Province, 510006, PR China
通讯作者：
推荐引用方式(GB/T 7714)：
Xian-Wen Yang,Fei Wang,Ru-Zi Qin,et al.Elevated serum CCL4/MIP-1β levels in postmenopausal osteoporosis patients are linked with disease severity.[J].Biomarkers in medicine.2019,13(1):17-25.doi:10.2217/bmm-2018-0250.
APA：
Xian-Wen Yang,Fei Wang,Ru-Zi Qin,Qi-Lin Zhou&Hong-Xing Huang.(2019).Elevated serum CCL4/MIP-1β levels in postmenopausal osteoporosis patients are linked with disease severity..Biomarkers in medicine,13,(1)
MLA：
Xian-Wen Yang,et al."Elevated serum CCL4/MIP-1β levels in postmenopausal osteoporosis patients are linked with disease severity.".Biomarkers in medicine 13..1(2019):17-25
