个人中心| | 帮助
高级检索
当前位置： 首页 > 详情页

Apple polysaccharide protects ICR mice against colitis associated colorectal cancer through the regulation of microbial dysbiosis.

| 认领 | 导出 | |

文献详情

资源类型：
Pubmed体系：

收录情况： ◇ EI

作者：
Yuhua Li[a,d] * ; Sheng Wang[b,c] * ; Yang Sun[e] * ; Wenqi Xu[b,c] ; Hongnan Zheng[d] ; Yan Wang[b,c] ; Yuan Tang[d] ; Xiaowei Gao[a] ; Can Song[a] ; Yin Long[f] ; Jiayun Liu[f] ; Li Liu[b,c,*1] ; Qibing Mei[a] ;
机构： [a]Department of Microbial and Biochemical Pharmacy, School of Pharmacy, Southwest Medial University, Luzhou, 646000 Sichuan, PR China [b]State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai, 200437, PR China [c]Shanghai Professional and Technical Service Center for Biological Material Drug-ability Evaluation, Shanghai, 200437, PR China [d]Department of Pharmacy, the First Naval Force Hospital of Southern Theatre Command, Zhanjiang, 524005 Guangdong, PR China [e]Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditional Chinese Medicine, Department of Pharmacology, School of Pharmacy, the Fourth Military Medical University, Xi’an, 710032 Shaanxi, PR China [f]Xijing Hospital, the Fourth Military Medical University, Xi’an, 710032 Shaanxi, PR China
出处：
DOI： 10.1016/j.carbpol.2019.115726
ISSN：

关键词： Apple polysaccharide Colitis associated colorectal cancer Bacteria

摘要：
The study tried to investigate whether apple polysaccharide (AP) could prevent colitis associated colorectal cancer (CACC) through the regulation of intestinal microbiota disorders. 10 % AP (w/v) was administrated to ICR mice by gavage for 15 wk. It was found that AP treatment protected against CACC in mice effectively. The level of Lactobacillus in the intestine of AOM/DSS-treated mice was significantly decreased and that of Fusobacterium increased; while AP could reverse this trend and increase the intestinal microbiota diversity. The number of T cells and macrophages in the colon tissue of mice in AOM/DSS group elevated; while AP could reduce the number of these cells significantly. AP suppressed nuclear aggregation of β-catenin, inhibited the activation of Wnt pathway in colon tissues. These data suggest that AP prevented ICR mice from CACC at least in part through regulating intestinal flora disorder and Wnt pathway. Copyright © 2019 Elsevier Ltd. All rights reserved.

基金：
This investigation was supported by the grant (No. 81302787), from National Natural Science Foundation of China, the grant (No. 2018M633405) from Postdoctoral Science Foundation of China, and the grant from Shanghai Professional and Technical Service Center for Biological Material Drug-ability Evaluation (No. 18DZ2290900).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类 | 2 区 工程技术
小类 | 1 区 应用化学 1 区 高分子科学 2 区 有机化学
最新[2025]版：
大类 | 1 区 化学
小类 | 1 区 应用化学 1 区 有机化学 1 区 高分子科学
第一作者：
第一作者机构： [a]Department of Microbial and Biochemical Pharmacy, School of Pharmacy, Southwest Medial University, Luzhou, 646000 Sichuan, PR China [d]Department of Pharmacy, the First Naval Force Hospital of Southern Theatre Command, Zhanjiang, 524005 Guangdong, PR China
共同第一作者：
通讯作者：
通讯机构： [b]State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai, 200437, PR China [c]Shanghai Professional and Technical Service Center for Biological Material Drug-ability Evaluation, Shanghai, 200437, PR China [*1]China State Institute of Pharmaceutical Industry, Biological substance evaluation and research center, Shanghai, 200040, PR China.
推荐引用方式(GB/T 7714)：
Yuhua Li,Sheng Wang,Yang Sun,et al.Apple polysaccharide protects ICR mice against colitis associated colorectal cancer through the regulation of microbial dysbiosis.[J].Carbohydrate polymers.2020,230:115726.doi:10.1016/j.carbpol.2019.115726.
APA：
Yuhua Li,Sheng Wang,Yang Sun,Wenqi Xu,Hongnan Zheng...&Qibing Mei.(2020).Apple polysaccharide protects ICR mice against colitis associated colorectal cancer through the regulation of microbial dysbiosis..Carbohydrate polymers,230,
MLA：
Yuhua Li,et al."Apple polysaccharide protects ICR mice against colitis associated colorectal cancer through the regulation of microbial dysbiosis.".Carbohydrate polymers 230.(2020):115726

相关文献

[1]Modified apple polysaccharide influences MUC-1 expression to prevent ICR mice from colitis-associated carcinogenesis. [2]Apple polysaccharide prevents from colitis-associated carcinogenesis through regulating macrophage polarization. [3]Apple polysaccharide could promote the growth of Bifidobacterium longum. [4]Shenling Baizhu San supresses colitis associated colorectal cancer through inhibition of epithelial-mesenchymal transition and myeloid-derived suppressor infiltration. [5]YYFZBJS inhibits colorectal tumorigenesis by enhancing Tregs-induced immunosuppression through HIF-1α mediated hypoxia in vivo and in vitro. [6]Modified apple polysaccharide prevents colitis through modulating IL-22 and IL-22BP expression. [7]Modified apple polysaccharide regulates microbial dysbiosis to suppress high-fat diet-induced obesity in C57BL/6J mice. [8]Corrigendum to "Apple polysaccharide prevents from colitis-associated carcinogenesis through regulating macrophage polarization" [Int. J. Biol. Macromol. 161C (2020) 704-711 [9]Recent advances in nanoantibiotics against multidrug-resistant bacteria [10]Saturated long-chain fatty acid-producing bacteria contribute to enhanced colonic motility in rats

资源点击量：2018 今日访问量：0 总访问量：645 更新日期：2024-07-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 广东省中医院 技术支持：重庆聚合科技有限公司 地址：广州市越秀区大德路111号